000 02315 a2200625 4500
005 20250517194150.0
264 0 _c20200427
008 202004s 0 0 eng d
022 _a1539-2864
024 7 _a10.1097/IAE.0000000000002027
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aNti, Akosua A
245 0 0 _aFREQUENT SUBCLINICAL MACULAR CHANGES IN COMBINED BRAF/MEK INHIBITION WITH HIGH-DOSE HYDROXYCHLOROQUINE AS TREATMENT FOR ADVANCED METASTATIC BRAF MUTANT MELANOMA: Preliminary Results From a Phase I/II Clinical Treatment Trial.
_h[electronic resource]
260 _bRetina (Philadelphia, Pa.)
_cMar 2019
300 _a502-513 p.
_bdigital
500 _aPublication Type: Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article
650 0 4 _aAdult
650 0 4 _aAged
650 0 4 _aAntineoplastic Agents
_xadverse effects
650 0 4 _aEnzyme Inhibitors
_xadverse effects
650 0 4 _aFemale
650 0 4 _aHumans
650 0 4 _aHydroxychloroquine
_xadverse effects
650 0 4 _aImidazoles
_xadverse effects
650 0 4 _aMAP Kinase Kinase 1
_xantagonists & inhibitors
650 0 4 _aMacula Lutea
_xpathology
650 0 4 _aMale
650 0 4 _aMelanoma
_xdrug therapy
650 0 4 _aMiddle Aged
650 0 4 _aOximes
_xadverse effects
650 0 4 _aPhotoreceptor Cells
_xpathology
650 0 4 _aProtein Kinase Inhibitors
_xadverse effects
650 0 4 _aProto-Oncogene Proteins B-raf
_xantagonists & inhibitors
650 0 4 _aPyridones
_xadverse effects
650 0 4 _aPyrimidinones
_xadverse effects
650 0 4 _aRetinal Diseases
_xchemically induced
650 0 4 _aRetinal Pigment Epithelium
_xpathology
700 1 _aSerrano, Leona W
700 1 _aSandhu, Harpal S
700 1 _aUyhazi, Katherine E
700 1 _aEdelstein, Ilaina D
700 1 _aZhou, Elaine J
700 1 _aBowman, Scott
700 1 _aSong, Delu
700 1 _aGangadhar, Tara C
700 1 _aSchuchter, Lynn M
700 1 _aMitnick, Sheryl
700 1 _aHuang, Alexander
700 1 _aNichols, Charles W
700 1 _aAmaravadi, Ravi K
700 1 _aKim, Benjamin J
700 1 _aAleman, Tomas S
773 0 _tRetina (Philadelphia, Pa.)
_gvol. 39
_gno. 3
_gp. 502-513
856 4 0 _uhttps://doi.org/10.1097/IAE.0000000000002027
_zAvailable from publisher's website
999 _c27970814
_d27970814