000 01924 a2200577 4500
005 20250517193055.0
264 0 _c20180907
008 201809s 0 0 eng d
022 _a1464-3391
024 7 _a10.1016/j.bmc.2017.12.015
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aClarke, Earl
245 0 0 _aDesign and synthesis of a potent, highly selective, orally bioavailable, retinoic acid receptor alpha agonist.
_h[electronic resource]
260 _bBioorganic & medicinal chemistry
_c02 2018
300 _a798-814 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, Non-U.S. Gov't
650 0 4 _aAdministration, Oral
650 0 4 _aAminobenzoates
_xchemistry
650 0 4 _aAnimals
650 0 4 _aBenzoates
_xchemistry
650 0 4 _aCOS Cells
650 0 4 _aCell Survival
_xdrug effects
650 0 4 _aChlorocebus aethiops
650 0 4 _aDrug Design
650 0 4 _aHalf-Life
650 0 4 _aHep G2 Cells
650 0 4 _aHumans
650 0 4 _aMice
650 0 4 _aMicrosomes, Liver
_xmetabolism
650 0 4 _aRats
650 0 4 _aReceptors, Retinoic Acid
_xagonists
650 0 4 _aRetinoic Acid Receptor alpha
_xagonists
650 0 4 _aStructure-Activity Relationship
650 0 4 _aTetrahydronaphthalenes
_xchemistry
650 0 4 _aRetinoic Acid Receptor gamma
700 1 _aJarvis, Christopher I
700 1 _aGoncalves, Maria B
700 1 _aKalindjian, S Barret
700 1 _aAdams, David R
700 1 _aBrown, Jane T
700 1 _aShiers, Jason J
700 1 _aTaddei, David M A
700 1 _aRavier, Elodie
700 1 _aBarlow, Stephanie
700 1 _aMiller, Iain
700 1 _aSmith, Vanessa
700 1 _aBorthwick, Alan D
700 1 _aCorcoran, Jonathan P T
773 0 _tBioorganic & medicinal chemistry
_gvol. 26
_gno. 4
_gp. 798-814
856 4 0 _uhttps://doi.org/10.1016/j.bmc.2017.12.015
_zAvailable from publisher's website
999 _c27935188
_d27935188