000 01672 a2200457 4500
005 20250517190842.0
264 0 _c20190415
008 201904s 0 0 eng d
022 _a1520-4804
024 7 _a10.1021/acs.jmedchem.7b00738
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aNeelarapu, Raghupathi
245 0 0 _aDesign and Synthesis of Orally Bioavailable Piperazine Substituted 4(1H)-Quinolones with Potent Antimalarial Activity: Structure-Activity and Structure-Property Relationship Studies.
_h[electronic resource]
260 _bJournal of medicinal chemistry
_c02 2018
300 _a1450-1473 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
650 0 4 _aAnimals
650 0 4 _aAntimalarials
_xchemical synthesis
650 0 4 _aDrug Design
650 0 4 _aHumans
650 0 4 _aMice
650 0 4 _aPiperazine
_xchemistry
650 0 4 _aPlasmodium falciparum
_xdrug effects
650 0 4 _aQuinolones
_xchemistry
650 0 4 _aSolubility
650 0 4 _aStructure-Activity Relationship
700 1 _aMaignan, Jordany R
700 1 _aLichorowic, Cynthia L
700 1 _aMonastyrskyi, Andrii
700 1 _aMutka, Tina S
700 1 _aLaCrue, Alexis N
700 1 _aBlake, Lynn D
700 1 _aCasandra, Debora
700 1 _aMashkouri, Sherwin
700 1 _aBurrows, Jeremy N
700 1 _aWillis, Paul A
700 1 _aKyle, Dennis E
700 1 _aManetsch, Roman
773 0 _tJournal of medicinal chemistry
_gvol. 61
_gno. 4
_gp. 1450-1473
856 4 0 _uhttps://doi.org/10.1021/acs.jmedchem.7b00738
_zAvailable from publisher's website
999 _c27864216
_d27864216