000 02279 a2200625 4500
005 20250517185622.0
264 0 _c20180926
008 201809s 0 0 eng d
022 _a1558-1497
024 7 _a10.1016/j.neurobiolaging.2017.10.021
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aTakata, Kazuyuki
245 0 0 _aAlpha7 nicotinic acetylcholine receptor-specific agonist DMXBA (GTS-21) attenuates Aβ accumulation through suppression of neuronal γ-secretase activity and promotion of microglial amyloid-β phagocytosis and ameliorates cognitive impairment in a mouse model of Alzheimer's disease.
_h[electronic resource]
260 _bNeurobiology of aging
_c02 2018
300 _a197-209 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, Non-U.S. Gov't
650 0 4 _aAlzheimer Disease
_xcomplications
650 0 4 _aAmyloid Precursor Protein Secretases
_xmetabolism
650 0 4 _aAmyloid beta-Peptides
_ximmunology
650 0 4 _aAnimals
650 0 4 _aBenzylidene Compounds
_xpharmacology
650 0 4 _aBrain
_xmetabolism
650 0 4 _aCells, Cultured
650 0 4 _aCognitive Dysfunction
_xdrug therapy
650 0 4 _aDisease Models, Animal
650 0 4 _aHumans
650 0 4 _aMice, Transgenic
650 0 4 _aMicroglia
_ximmunology
650 0 4 _aNeuroblastoma
_xmetabolism
650 0 4 _aPhagocytosis
_xdrug effects
650 0 4 _aPyridines
_xpharmacology
650 0 4 _aRats
650 0 4 _aTumor Cells, Cultured
650 0 4 _aalpha7 Nicotinic Acetylcholine Receptor
_xagonists
700 1 _aAmamiya, Takahide
700 1 _aMizoguchi, Hiroaki
700 1 _aKawanishi, Shohei
700 1 _aKuroda, Eriko
700 1 _aKitamura, Risa
700 1 _aIto, Aina
700 1 _aSaito, Yuki
700 1 _aTawa, Manami
700 1 _aNagasawa, Tomofumi
700 1 _aOkamoto, Haruka
700 1 _aSugino, Yuko
700 1 _aTakegami, Shigehiko
700 1 _aKitade, Tatsuya
700 1 _aToda, Yuki
700 1 _aKem, William R
700 1 _aKitamura, Yoshihisa
700 1 _aShimohama, Shun
700 1 _aAshihara, Eishi
773 0 _tNeurobiology of aging
_gvol. 62
_gp. 197-209
856 4 0 _uhttps://doi.org/10.1016/j.neurobiolaging.2017.10.021
_zAvailable from publisher's website
999 _c27825420
_d27825420