000 02055 a2200565 4500
005 20250517184616.0
264 0 _c20180907
008 201809s 0 0 eng d
022 _a2041-1723
024 7 _a10.1038/s41467-017-01671-5
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aFu, Chengzhang
245 0 0 _aThe natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD.
_h[electronic resource]
260 _bNature communications
_c11 2017
300 _a1529 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, Non-U.S. Gov't
650 0 4 _aAminohydrolases
_xmetabolism
650 0 4 _aAnti-Bacterial Agents
_xpharmacology
650 0 4 _aAntineoplastic Agents
_xpharmacology
650 0 4 _aBacterial Proteins
_xmetabolism
650 0 4 _aBiofilms
_xdrug effects
650 0 4 _aBiological Products
_xpharmacology
650 0 4 _aCell Line, Tumor
650 0 4 _aCrystallography, X-Ray
650 0 4 _aEnzyme Assays
650 0 4 _aFolic Acid
_xmetabolism
650 0 4 _aFormate-Tetrahydrofolate Ligase
_xmetabolism
650 0 4 _aHumans
650 0 4 _aInhibitory Concentration 50
650 0 4 _aMacrolides
_xpharmacology
650 0 4 _aMethylenetetrahydrofolate Dehydrogenase (NADP)
_xmetabolism
650 0 4 _aMicrobial Sensitivity Tests
650 0 4 _aMinor Histocompatibility Antigens
_xmetabolism
650 0 4 _aMitochondria
_xmetabolism
650 0 4 _aMultienzyme Complexes
_xmetabolism
650 0 4 _aMultifunctional Enzymes
_xmetabolism
650 0 4 _aMyxococcales
_xmetabolism
650 0 4 _aNeoplasms
_xdrug therapy
650 0 4 _aProtein Binding
700 1 _aSikandar, Asfandyar
700 1 _aDonner, Jannik
700 1 _aZaburannyi, Nestor
700 1 _aHerrmann, Jennifer
700 1 _aReck, Michael
700 1 _aWagner-Döbler, Irene
700 1 _aKoehnke, Jesko
700 1 _aMüller, Rolf
773 0 _tNature communications
_gvol. 8
_gno. 1
_gp. 1529
856 4 0 _uhttps://doi.org/10.1038/s41467-017-01671-5
_zAvailable from publisher's website
999 _c27792630
_d27792630