000			01995 a2200565 4500
005			20250517183015.0
264		0	_c20171229
008			201712s 0 0 eng d
022			_a1520-4804
024	7		_a10.1021/acs.jmedchem.7b01304 _2doi
040			_aNLM _beng _cNLM
100	1		_aBueno, Ana B
245	0	0	_aOptimization of Hydroxyethylamine Transition State Isosteres as Aspartic Protease Inhibitors by Exploiting Conformational Preferences. _h[electronic resource]
260			_bJournal of medicinal chemistry _c12 2017
300			_a9807-9820 p. _bdigital
500			_aPublication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't
650	0	4	_aAmyloid Precursor Protein Secretases _xantagonists & inhibitors
650	0	4	_aAnimals
650	0	4	_aAspartic Acid Endopeptidases _xantagonists & inhibitors
650	0	4	_aBrain _xmetabolism
650	0	4	_aCrystallography, X-Ray
650	0	4	_aCyclization
650	0	4	_aDrug Design
650	0	4	_aEthylamines _xchemistry
650	0	4	_aHumans
650	0	4	_aMagnetic Resonance Spectroscopy
650	0	4	_aMice
650	0	4	_aModels, Molecular
650	0	4	_aMorpholines _xchemistry
650	0	4	_aPeptides _xchemistry
650	0	4	_aProtease Inhibitors _xchemistry
650	0	4	_aStructure-Activity Relationship
700	1		_aAgejas, Javier
700	1		_aBroughton, Howard
700	1		_aDally, Robert
700	1		_aDurham, Timothy B
700	1		_aEspinosa, Juan Félix
700	1		_aGonzález, Rosario
700	1		_aHahn, Patric J
700	1		_aMarcos, Alicia
700	1		_aRodríguez, Ramón
700	1		_aSanz, Gema
700	1		_aSoriano, José F
700	1		_aTimm, David
700	1		_aVidal, Paloma
700	1		_aYang, Hsiu-Chiung
700	1		_aMcCarthy, James R
773	0		_tJournal of medicinal chemistry _gvol. 60 _gno. 23 _gp. 9807-9820
856	4	0	_uhttps://doi.org/10.1021/acs.jmedchem.7b01304 _zAvailable from publisher's website
999			_c27739843 _d27739843