000			01978 a2200541 4500
005			20250517182420.0
264		0	_c20190130
008			201901s 0 0 eng d
022			_a1096-0929
024	7		_a10.1093/toxsci/kfx222 _2doi
040			_aNLM _beng _cNLM
100	1		_aMosedale, Merrie
245	0	0	_aTransient Changes in Hepatic Physiology That Alter Bilirubin and Bile Acid Transport May Explain Elevations in Liver Chemistries Observed in Clinical Trials of GGF2 (Cimaglermin Alfa). _h[electronic resource]
260			_bToxicological sciences : an official journal of the Society of Toxicology _c02 2018
300			_a401-411 p. _bdigital
500			_aPublication Type: Journal Article; Research Support, Non-U.S. Gov't
650	0	4	_aAnimals
650	0	4	_aBile Acids and Salts _xblood
650	0	4	_aBile Ducts _xdrug effects
650	0	4	_aBilirubin _xblood
650	0	4	_aBiological Transport
650	0	4	_aCell Survival _xdrug effects
650	0	4	_aClinical Trials, Phase I as Topic
650	0	4	_aCytochrome P-450 CYP3A _xgenetics
650	0	4	_aHep G2 Cells
650	0	4	_aHepatocytes _xdrug effects
650	0	4	_aHumans
650	0	4	_aLiver _xdrug effects
650	0	4	_aMacaca fascicularis
650	0	4	_aMale
650	0	4	_aNeuregulin-1 _xadverse effects
650	0	4	_aPrimary Cell Culture
650	0	4	_aToxicogenetics
650	0	4	_aTranscriptome _xdrug effects
700	1		_aButton, Donald
700	1		_aJackson, Jonathan P
700	1		_aFreeman, Kimberly M
700	1		_aBrouwer, Kenneth R
700	1		_aCaggiano, Anthony O
700	1		_aEisen, Andrew
700	1		_aIaci, Jennifer F
700	1		_aParry, Tom J
700	1		_aStanulis, Ric
700	1		_aSrinivas, Maya
700	1		_aWatkins, Paul B
773	0		_tToxicological sciences : an official journal of the Society of Toxicology _gvol. 161 _gno. 2 _gp. 401-411
856	4	0	_uhttps://doi.org/10.1093/toxsci/kfx222 _zAvailable from publisher's website
999			_c27721614 _d27721614