000 01688 a2200457 4500
005 20250517181816.0
264 0 _c20171121
008 201711s 0 0 eng d
022 _a1464-3405
024 7 _a10.1016/j.bmcl.2017.10.009
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aCook, James
245 0 0 _aDesign and synthesis of a novel series of (1'S,2R,4'S)-3H-4'-azaspiro[benzo[4,5]imidazo[2,1-b]oxazole-2,2'-bicyclo[2.2.2]octanes] with high affinity for the α7 neuronal nicotinic receptor.
_h[electronic resource]
260 _bBioorganic & medicinal chemistry letters
_c11 2017
300 _a5002-5005 p.
_bdigital
500 _aPublication Type: Journal Article
650 0 4 _aBridged Bicyclo Compounds
_xchemical synthesis
650 0 4 _aCrystallography, X-Ray
650 0 4 _aDrug Design
650 0 4 _aHumans
650 0 4 _aHydrogen Bonding
650 0 4 _aMolecular Conformation
650 0 4 _aNicotinic Agonists
_xchemistry
650 0 4 _aOctanes
_xchemical synthesis
650 0 4 _aProtein Binding
650 0 4 _aReceptors, Serotonin, 5-HT3
_xchemistry
650 0 4 _aStereoisomerism
650 0 4 _aalpha7 Nicotinic Acetylcholine Receptor
_xchemistry
700 1 _aZusi, F Christopher
700 1 _aHill, Matthew D
700 1 _aFang, Haiquan
700 1 _aPearce, Bradley
700 1 _aPark, Hyunsoo
700 1 _aGallagher, Lizbeth
700 1 _aMcDonald, Ivar M
700 1 _aBristow, Linda
700 1 _aMacor, John E
700 1 _aOlson, Richard E
773 0 _tBioorganic & medicinal chemistry letters
_gvol. 27
_gno. 22
_gp. 5002-5005
856 4 0 _uhttps://doi.org/10.1016/j.bmcl.2017.10.009
_zAvailable from publisher's website
999 _c27703189
_d27703189