000 02262 a2200733 4500
005 20250517181212.0
264 0 _c20171206
008 201712s 0 0 eng d
022 _a1464-3405
024 7 _a10.1016/j.bmcl.2017.09.056
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aStorer, R Ian
245 0 0 _aHighly potent and selective Na
_h[electronic resource]
260 _bBioorganic & medicinal chemistry letters
_c11 2017
300 _a4805-4811 p.
_bdigital
500 _aPublication Type: Journal Article
650 0 4 _aAnimals
650 0 4 _aBinding Sites
650 0 4 _aDogs
650 0 4 _aHalf-Life
650 0 4 _aHepatocytes
_xmetabolism
650 0 4 _aHumans
650 0 4 _aInfusions, Intravenous
650 0 4 _aInhibitory Concentration 50
650 0 4 _aMice
650 0 4 _aMicrosomes, Liver
_xmetabolism
650 0 4 _aMolecular Docking Simulation
650 0 4 _aNAV1.7 Voltage-Gated Sodium Channel
_xchemistry
650 0 4 _aPain
_xdrug therapy
650 0 4 _aPiperidines
_xchemistry
650 0 4 _aProtein Binding
650 0 4 _aProtein Structure, Tertiary
650 0 4 _aPyridines
_xchemistry
650 0 4 _aRats
650 0 4 _aStructure-Activity Relationship
650 0 4 _aSulfonamides
_xchemistry
650 0 4 _aThiadiazoles
650 0 4 _aVoltage-Gated Sodium Channel Blockers
_xchemistry
700 1 _aPike, Andy
700 1 _aSwain, Nigel A
700 1 _aAlexandrou, Aristos J
700 1 _aBechle, Bruce M
700 1 _aBlakemore, David C
700 1 _aBrown, Alan D
700 1 _aCastle, Neil A
700 1 _aCorbett, Matthew S
700 1 _aFlanagan, Neil J
700 1 _aFengas, David
700 1 _aJohnson, M Scott
700 1 _aJones, Lyn H
700 1 _aMarron, Brian E
700 1 _aPayne, C Elizabeth
700 1 _aPrintzenhoff, David
700 1 _aRawson, David J
700 1 _aRose, Colin R
700 1 _aRyckmans, Thomas
700 1 _aSun, Jianmin
700 1 _aTheile, Jonathan W
700 1 _aTorella, Rubben
700 1 _aTseng, Elaine
700 1 _aWarmus, Joseph S
773 0 _tBioorganic & medicinal chemistry letters
_gvol. 27
_gno. 21
_gp. 4805-4811
856 4 0 _uhttps://doi.org/10.1016/j.bmcl.2017.09.056
_zAvailable from publisher's website
999 _c27682711
_d27682711