000 01802 a2200481 4500
005 20250517170257.0
264 0 _c20171103
008 201711s 0 0 eng d
022 _a1699-3993
024 7 _a10.1358/dot.2017.53.6.2652413
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aPaton, D M
245 0 0 _aNusinersen: antisense oligonucleotide to increase SMN protein production in spinal muscular atrophy.
_h[electronic resource]
260 _bDrugs of today (Barcelona, Spain : 1998)
_cJun 2017
300 _a327-337 p.
_bdigital
500 _aPublication Type: Journal Article; Review
650 0 4 _aAdult
650 0 4 _aAlternative Splicing
_xdrug effects
650 0 4 _aAnimals
650 0 4 _aCentral Nervous System
_xmetabolism
650 0 4 _aClinical Trials as Topic
650 0 4 _aDrug Evaluation, Preclinical
650 0 4 _aExons
650 0 4 _aGene Dosage
650 0 4 _aHaplorhini
650 0 4 _aHumans
650 0 4 _aInfant
650 0 4 _aInjections, Spinal
650 0 4 _aKidney Diseases
_xchemically induced
650 0 4 _aMice
650 0 4 _aMulticenter Studies as Topic
650 0 4 _aOligonucleotides
_xadministration & dosage
650 0 4 _aOligonucleotides, Antisense
_xadministration & dosage
650 0 4 _aProtein Stability
650 0 4 _aSpinal Muscular Atrophies of Childhood
_xgenetics
650 0 4 _aSurvival of Motor Neuron 1 Protein
_xgenetics
650 0 4 _aSurvival of Motor Neuron 2 Protein
_xbiosynthesis
650 0 4 _aThionucleotides
_xadministration & dosage
650 0 4 _aThrombocytopenia
_xchemically induced
650 0 4 _aUp-Regulation
_xdrug effects
773 0 _tDrugs of today (Barcelona, Spain : 1998)
_gvol. 53
_gno. 6
_gp. 327-337
856 4 0 _uhttps://doi.org/10.1358/dot.2017.53.6.2652413
_zAvailable from publisher's website
999 _c27457131
_d27457131