000 02024 a2200553 4500
005 20250517164107.0
264 0 _c20170926
008 201709s 0 0 eng d
022 _a1083-351X
024 7 _a10.1074/jbc.M117.783555
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aHiruma, Yoshitaka
245 0 0 _aUnderstanding inhibitor resistance in Mps1 kinase through novel biophysical assays and structures.
_h[electronic resource]
260 _bThe Journal of biological chemistry
_c09 2017
300 _a14496-14504 p.
_bdigital
500 _aPublication Type: Comparative Study; Journal Article
650 0 4 _aAdenosine Triphosphate
_xchemistry
650 0 4 _aAmino Acid Substitution
650 0 4 _aAntineoplastic Agents
_xchemistry
650 0 4 _aBinding Sites
650 0 4 _aCatalytic Domain
650 0 4 _aCell Cycle Proteins
_xantagonists & inhibitors
650 0 4 _aCrystallography, X-Ray
650 0 4 _aHumans
650 0 4 _aKinetics
650 0 4 _aLigands
650 0 4 _aModels, Molecular
650 0 4 _aMolecular Structure
650 0 4 _aMorpholines
_xchemistry
650 0 4 _aPhosphorylation
_xdrug effects
650 0 4 _aPoint Mutation
650 0 4 _aProtein Kinase Inhibitors
_xchemistry
650 0 4 _aProtein Processing, Post-Translational
_xdrug effects
650 0 4 _aProtein Serine-Threonine Kinases
_xantagonists & inhibitors
650 0 4 _aProtein-Tyrosine Kinases
_xantagonists & inhibitors
650 0 4 _aPurines
_xchemistry
650 0 4 _aPyrazoles
_xchemistry
650 0 4 _aQuinazolines
_xchemistry
650 0 4 _aRecombinant Fusion Proteins
_xchemistry
650 0 4 _aRecombinant Proteins
_xchemistry
700 1 _aKoch, Andre
700 1 _aHazraty, Nazila
700 1 _aTsakou, Foteini
700 1 _aMedema, René H
700 1 _aJoosten, Robbie P
700 1 _aPerrakis, Anastassis
773 0 _tThe Journal of biological chemistry
_gvol. 292
_gno. 35
_gp. 14496-14504
856 4 0 _uhttps://doi.org/10.1074/jbc.M117.783555
_zAvailable from publisher's website
999 _c27385916
_d27385916