000 01939 a2200493 4500
005 20250517162144.0
264 0 _c20190214
008 201902s 0 0 eng d
022 _a1475-6374
024 7 _a10.1080/14756366.2017.1334650
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aGhorab, Mostafa M
245 0 0 _aVEGFR-2 inhibitors and apoptosis inducers: synthesis and molecular design of new benzo[g]quinazolin bearing benzenesulfonamide moiety.
_h[electronic resource]
260 _bJournal of enzyme inhibition and medicinal chemistry
_cDec 2017
300 _a893-907 p.
_bdigital
500 _aPublication Type: Comparative Study; Journal Article
650 0 4 _aAntineoplastic Agents
_xchemical synthesis
650 0 4 _aApoptosis
_xdrug effects
650 0 4 _aBreast
_xcytology
650 0 4 _aCaspase 3
_xmetabolism
650 0 4 _aCatalytic Domain
650 0 4 _aCell Cycle Checkpoints
_xdrug effects
650 0 4 _aCell Line
650 0 4 _aDrug Screening Assays, Antitumor
650 0 4 _aEnzyme Activation
650 0 4 _aHumans
650 0 4 _aInhibitory Concentration 50
650 0 4 _aMCF-7 Cells
650 0 4 _aMolecular Docking Simulation
650 0 4 _aPiperidines
_xpharmacology
650 0 4 _aProtein Kinase Inhibitors
_xchemical synthesis
650 0 4 _aProto-Oncogene Proteins c-bcl-2
_xmetabolism
650 0 4 _aQuinazolines
_xchemical synthesis
650 0 4 _aSpectrum Analysis
_xmethods
650 0 4 _aSulfonamides
_xchemistry
650 0 4 _aVascular Endothelial Growth Factor Receptor-2
_xantagonists & inhibitors
650 0 4 _abcl-2-Associated X Protein
_xmetabolism
650 0 4 _aBenzenesulfonamides
700 1 _aAlsaid, Mansour S
700 1 _aSoliman, Aiten M
700 1 _aRagab, Fatma A
773 0 _tJournal of enzyme inhibition and medicinal chemistry
_gvol. 32
_gno. 1
_gp. 893-907
856 4 0 _uhttps://doi.org/10.1080/14756366.2017.1334650
_zAvailable from publisher's website
999 _c27322760
_d27322760