000 01881 a2200529 4500
005 20250517155806.0
264 0 _c20170919
008 201709s 0 0 eng d
022 _a1932-6203
024 7 _a10.1371/journal.pone.0178905
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aWang, Jianxun
245 0 0 _aIn vivo efficacy of the AKT inhibitor ARQ 092 in Noonan Syndrome with multiple lentigines-associated hypertrophic cardiomyopathy.
_h[electronic resource]
260 _bPloS one
_c2017
300 _ae0178905 p.
_bdigital
500 _aPublication Type: Journal Article
650 0 4 _aAlleles
650 0 4 _aAminopyridines
_xpharmacology
650 0 4 _aAnimals
650 0 4 _aCardiomyopathy, Hypertrophic
_xdiagnostic imaging
650 0 4 _aCardiotonic Agents
_xpharmacology
650 0 4 _aDisease Models, Animal
650 0 4 _aEchocardiography
650 0 4 _aGene Expression Regulation
650 0 4 _aHumans
650 0 4 _aImidazoles
_xpharmacology
650 0 4 _aLEOPARD Syndrome
_xdiagnostic imaging
650 0 4 _aMale
650 0 4 _aMice
650 0 4 _aMice, Transgenic
650 0 4 _aMutation
650 0 4 _aMyocytes, Cardiac
_xdrug effects
650 0 4 _aPhosphoproteins
_xantagonists & inhibitors
650 0 4 _aProtein Domains
650 0 4 _aProtein Kinase Inhibitors
_xpharmacology
650 0 4 _aProtein Tyrosine Phosphatase, Non-Receptor Type 11
_xgenetics
650 0 4 _aProto-Oncogene Proteins c-akt
_xantagonists & inhibitors
650 0 4 _aSignal Transduction
650 0 4 _aTOR Serine-Threonine Kinases
_xgenetics
700 1 _aChandrasekhar, Vasanth
700 1 _aAbbadessa, Giovanni
700 1 _aYu, Yi
700 1 _aSchwartz, Brian
700 1 _aKontaridis, Maria I
773 0 _tPloS one
_gvol. 12
_gno. 6
_gp. e0178905
856 4 0 _uhttps://doi.org/10.1371/journal.pone.0178905
_zAvailable from publisher's website
999 _c27246938
_d27246938