000 02336 a2200721 4500
005 20250517154944.0
264 0 _c20170828
008 201708s 0 0 eng d
022 _a1529-2916
024 7 _a10.1038/ni.3766
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aGorman, Jacquelyn A
245 0 0 _aThe A946T variant of the RNA sensor IFIH1 mediates an interferon program that limits viral infection but increases the risk for autoimmunity.
_h[electronic resource]
260 _bNature immunology
_cJul 2017
300 _a744-752 p.
_bdigital
500 _aPublication Type: Journal Article
650 0 4 _aAdolescent
650 0 4 _aAdult
650 0 4 _aAnimals
650 0 4 _aAutoimmune Diseases
_xgenetics
650 0 4 _aAutoimmunity
_xgenetics
650 0 4 _aBlotting, Southern
650 0 4 _aCardiovirus Infections
_xgenetics
650 0 4 _aDiabetes Mellitus, Experimental
_xgenetics
650 0 4 _aDiabetes Mellitus, Type 1
_xgenetics
650 0 4 _aEncephalomyocarditis virus
_ximmunology
650 0 4 _aFemale
650 0 4 _aGenetic Predisposition to Disease
650 0 4 _aHEK293 Cells
650 0 4 _aHumans
650 0 4 _aImmunoblotting
650 0 4 _aInterferon Type I
_ximmunology
650 0 4 _aInterferon-Induced Helicase, IFIH1
_xgenetics
650 0 4 _aMale
650 0 4 _aMice
650 0 4 _aMiddle Aged
650 0 4 _aPolymorphism, Single Nucleotide
650 0 4 _aReal-Time Polymerase Chain Reaction
650 0 4 _aReverse Transcriptase Polymerase Chain Reaction
650 0 4 _aVirus Diseases
_xgenetics
650 0 4 _aYoung Adult
700 1 _aHundhausen, Christian
700 1 _aErrett, John S
700 1 _aStone, Amy E
700 1 _aAllenspach, Eric J
700 1 _aGe, Yan
700 1 _aArkatkar, Tanvi
700 1 _aClough, Courtnee
700 1 _aDai, Xuezhi
700 1 _aKhim, Socheath
700 1 _aPestal, Kathleen
700 1 _aLiggitt, Denny
700 1 _aCerosaletti, Karen
700 1 _aStetson, Daniel B
700 1 _aJames, Richard G
700 1 _aOukka, Mohamed
700 1 _aConcannon, Patrick
700 1 _aGale, Michael
700 1 _aBuckner, Jane H
700 1 _aRawlings, David J
773 0 _tNature immunology
_gvol. 18
_gno. 7
_gp. 744-752
856 4 0 _uhttps://doi.org/10.1038/ni.3766
_zAvailable from publisher's website
999 _c27219216
_d27219216