000 01898 a2200589 4500
005 20250517153427.0
264 0 _c20180406
008 201804s 0 0 eng d
022 _a1949-2553
024 7 _a10.18632/oncotarget.17464
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aZheng, Mengzhu
245 0 0 _aStructure based discovery of clomifene as a potent inhibitor of cancer-associated mutant IDH1.
_h[electronic resource]
260 _bOncotarget
_cJul 2017
300 _a44255-44265 p.
_bdigital
500 _aPublication Type: Journal Article
650 0 4 _aAnimals
650 0 4 _aAntineoplastic Agents
_xchemistry
650 0 4 _aBinding Sites
650 0 4 _aBiomarkers, Tumor
650 0 4 _aCell Line, Tumor
650 0 4 _aCell Proliferation
_xdrug effects
650 0 4 _aClomiphene
_xchemistry
650 0 4 _aEnzyme Activation
_xdrug effects
650 0 4 _aEnzyme Inhibitors
_xchemistry
650 0 4 _aGene Knockdown Techniques
650 0 4 _aHumans
650 0 4 _aInhibitory Concentration 50
650 0 4 _aIsocitrate Dehydrogenase
_xantagonists & inhibitors
650 0 4 _aMale
650 0 4 _aMice
650 0 4 _aModels, Molecular
650 0 4 _aMolecular Conformation
650 0 4 _aMolecular Docking Simulation
650 0 4 _aMolecular Dynamics Simulation
650 0 4 _aMutant Proteins
650 0 4 _aProtein Binding
650 0 4 _aStructure-Activity Relationship
650 0 4 _aSubstrate Specificity
650 0 4 _aXenograft Model Antitumor Assays
700 1 _aSun, Weiguang
700 1 _aGao, Suyu
700 1 _aLuan, Shanshan
700 1 _aLi, Dan
700 1 _aChen, Renqi
700 1 _aZhang, Qian
700 1 _aChen, Lixia
700 1 _aHuang, Jiangeng
700 1 _aLi, Hua
773 0 _tOncotarget
_gvol. 8
_gno. 27
_gp. 44255-44265
856 4 0 _uhttps://doi.org/10.18632/oncotarget.17464
_zAvailable from publisher's website
999 _c27168044
_d27168044