000 01573 a2200409 4500
005 20250517151300.0
264 0 _c20171219
008 201712s 0 0 eng d
022 _a1464-3405
024 7 _a10.1016/j.bmcl.2017.04.020
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aGhareb, Nagat
245 0 0 _aNovel pyrazoles and pyrazolo[1,2-a]pyridazines as selective COX-2 inhibitors; Ultrasound-assisted synthesis, biological evaluation, and DFT calculations.
_h[electronic resource]
260 _bBioorganic & medicinal chemistry letters
_c06 2017
300 _a2377-2383 p.
_bdigital
500 _aPublication Type: Journal Article
650 0 4 _aAnimals
650 0 4 _aAnti-Inflammatory Agents, Non-Steroidal
_xchemical synthesis
650 0 4 _aBinding Sites
_xdrug effects
650 0 4 _aCelecoxib
_xchemistry
650 0 4 _aCyclization
650 0 4 _aCyclooxygenase 2 Inhibitors
_xchemical synthesis
650 0 4 _aEnzyme Assays
650 0 4 _aHydrophobic and Hydrophilic Interactions
650 0 4 _aMolecular Docking Simulation
650 0 4 _aPyrazoles
_xchemical synthesis
650 0 4 _aPyridazines
_xchemical synthesis
650 0 4 _aQuantum Theory
650 0 4 _aQuinones
_xchemical synthesis
650 0 4 _aSpodoptera
650 0 4 _aUltrasonic Waves
700 1 _aElshihawy, Hosam A
700 1 _aAbdel-Daim, Mohamed M
700 1 _aHelal, Mohamed A
773 0 _tBioorganic & medicinal chemistry letters
_gvol. 27
_gno. 11
_gp. 2377-2383
856 4 0 _uhttps://doi.org/10.1016/j.bmcl.2017.04.020
_zAvailable from publisher's website
999 _c27098655
_d27098655