000 02491 a2200685 4500
005 20250517151217.0
264 0 _c20170918
008 201709s 0 0 eng d
022 _a1742-4658
024 7 _a10.1111/febs.14066
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aSeo, Tadahiko
245 0 0 _aHaemorrhagic snake venom metalloproteases and human ADAMs cleave LRP5/6, which disrupts cell-cell adhesions in vitro and induces haemorrhage in vivo.
_h[electronic resource]
260 _bThe FEBS journal
_c06 2017
300 _a1657-1671 p.
_bdigital
500 _aPublication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
650 0 4 _aADAM Proteins
_xmetabolism
650 0 4 _aADAM12 Protein
_xmetabolism
650 0 4 _aAmino Acid Sequence
650 0 4 _aAnimals
650 0 4 _aAntibodies, Neutralizing
_xpharmacology
650 0 4 _aApoptosis Regulatory Proteins
_xmetabolism
650 0 4 _aCell Adhesion
_xdrug effects
650 0 4 _aCrotalid Venoms
_xmetabolism
650 0 4 _aDrug Resistance
650 0 4 _aFibrinogen
_xmetabolism
650 0 4 _aFibronectins
_xmetabolism
650 0 4 _aHeLa Cells
650 0 4 _aHemorrhage
_xchemically induced
650 0 4 _aHuman Umbilical Vein Endothelial Cells
650 0 4 _aHumans
650 0 4 _aHydrophobic and Hydrophilic Interactions
650 0 4 _aLow Density Lipoprotein Receptor-Related Protein-5
_xchemistry
650 0 4 _aLow Density Lipoprotein Receptor-Related Protein-6
_xchemistry
650 0 4 _aMale
650 0 4 _aMembrane Proteins
_xmetabolism
650 0 4 _aMetalloendopeptidases
_xmetabolism
650 0 4 _aMice
650 0 4 _aModels, Molecular
650 0 4 _aMolecular Docking Simulation
650 0 4 _aProtein Domains
650 0 4 _aProtein Structure, Secondary
_xdrug effects
650 0 4 _aRecombinant Proteins
_xmetabolism
650 0 4 _aSequence Alignment
650 0 4 _aSequence Homology, Amino Acid
650 0 4 _aSpecies Specificity
650 0 4 _aVertebrates
_xmetabolism
650 0 4 _aWnt Signaling Pathway
_xdrug effects
700 1 _aSakon, Taketo
700 1 _aNakazawa, Shiori
700 1 _aNishioka, Asuka
700 1 _aWatanabe, Kohei
700 1 _aMatsumoto, Kaori
700 1 _aAkasaka, Mari
700 1 _aShioi, Narumi
700 1 _aSawada, Hitoshi
700 1 _aAraki, Satohiko
773 0 _tThe FEBS journal
_gvol. 284
_gno. 11
_gp. 1657-1671
856 4 0 _uhttps://doi.org/10.1111/febs.14066
_zAvailable from publisher's website
999 _c27096144
_d27096144