000 01857 a2200589 4500
005 20250517150557.0
264 0 _c20170822
008 201708s 0 0 eng d
022 _a1476-4687
024 7 _a10.1038/nature22038
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aBecker, Lindsay A
245 0 0 _aTherapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice.
_h[electronic resource]
260 _bNature
_c04 2017
300 _a367-371 p.
_bdigital
500 _aPublication Type: Journal Article
650 0 4 _aAmyotrophic Lateral Sclerosis
_xgenetics
650 0 4 _aAnimals
650 0 4 _aAtaxin-2
_xdeficiency
650 0 4 _aCentral Nervous System
_xmetabolism
650 0 4 _aCytoplasmic Granules
_xmetabolism
650 0 4 _aDNA-Binding Proteins
_xchemistry
650 0 4 _aDisease Progression
650 0 4 _aFemale
650 0 4 _aGene Knockdown Techniques
650 0 4 _aHumans
650 0 4 _aLongevity
650 0 4 _aMale
650 0 4 _aMice
650 0 4 _aMice, Knockout
650 0 4 _aMice, Transgenic
650 0 4 _aMotor Skills
_xphysiology
650 0 4 _aOligonucleotides, Antisense
_xadministration & dosage
650 0 4 _aProtein Aggregation, Pathological
_xgenetics
650 0 4 _aStress, Physiological
650 0 4 _aSurvival Analysis
700 1 _aHuang, Brenda
700 1 _aBieri, Gregor
700 1 _aMa, Rosanna
700 1 _aKnowles, David A
700 1 _aJafar-Nejad, Paymaan
700 1 _aMessing, James
700 1 _aKim, Hong Joo
700 1 _aSoriano, Armand
700 1 _aAuburger, Georg
700 1 _aPulst, Stefan M
700 1 _aTaylor, J Paul
700 1 _aRigo, Frank
700 1 _aGitler, Aaron D
773 0 _tNature
_gvol. 544
_gno. 7650
_gp. 367-371
856 4 0 _uhttps://doi.org/10.1038/nature22038
_zAvailable from publisher's website
999 _c27076618
_d27076618