000 02167 a2200613 4500
005 20250517144811.0
264 0 _c20181112
008 201811s 0 0 eng d
022 _a2045-2322
024 7 _a10.1038/srep44841
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aAlizadeh, Javad
245 0 0 _aMevalonate Cascade Inhibition by Simvastatin Induces the Intrinsic Apoptosis Pathway via Depletion of Isoprenoids in Tumor Cells.
_h[electronic resource]
260 _bScientific reports
_c03 2017
300 _a44841 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
650 0 4 _aAlkyl and Aryl Transferases
_xmetabolism
650 0 4 _aApoptosis
_xdrug effects
650 0 4 _aCell Death
_xdrug effects
650 0 4 _aCell Line, Tumor
650 0 4 _aCell Membrane
_xmetabolism
650 0 4 _aCholesterol
_xmetabolism
650 0 4 _aDose-Response Relationship, Drug
650 0 4 _aFarnesyltranstransferase
_xmetabolism
650 0 4 _aHumans
650 0 4 _aHydroxymethylglutaryl-CoA Reductase Inhibitors
_xpharmacology
650 0 4 _aMetabolic Networks and Pathways
_xdrug effects
650 0 4 _aMevalonic Acid
_xmetabolism
650 0 4 _aProtein Transport
650 0 4 _aSignal Transduction
_xdrug effects
650 0 4 _aSimvastatin
_xpharmacology
650 0 4 _aTerpenes
650 0 4 _arho GTP-Binding Proteins
_xmetabolism
700 1 _aZeki, Amir A
700 1 _aMirzaei, Nima
700 1 _aTewary, Sandipan
700 1 _aRezaei Moghadam, Adel
700 1 _aGlogowska, Aleksandra
700 1 _aNagakannan, Pandian
700 1 _aEftekharpour, Eftekhar
700 1 _aWiechec, Emilia
700 1 _aGordon, Joseph W
700 1 _aXu, Fred Y
700 1 _aField, Jared T
700 1 _aYoneda, Ken Y
700 1 _aKenyon, Nicholas J
700 1 _aHashemi, Mohammad
700 1 _aHatch, Grant M
700 1 _aHombach-Klonisch, Sabine
700 1 _aKlonisch, Thomas
700 1 _aGhavami, Saeid
773 0 _tScientific reports
_gvol. 7
_gp. 44841
856 4 0 _uhttps://doi.org/10.1038/srep44841
_zAvailable from publisher's website
999 _c27017368
_d27017368