000 02804 a2200817 4500
005 20250517134244.0
264 0 _c20171219
008 201712s 0 0 eng d
022 _a2159-8290
024 7 _a10.1158/2159-8290.CD-16-0653
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aZawistowski, Jon S
245 0 0 _aEnhancer Remodeling during Adaptive Bypass to MEK Inhibition Is Attenuated by Pharmacologic Targeting of the P-TEFb Complex.
_h[electronic resource]
260 _bCancer discovery
_c03 2017
300 _a302-321 p.
_bdigital
500 _aPublication Type: Clinical Trial; Journal Article
650 0 4 _aAnimals
650 0 4 _aAntineoplastic Agents
_xpharmacology
650 0 4 _aAzepines
_xpharmacology
650 0 4 _aCell Cycle Proteins
650 0 4 _aCell Line, Tumor
650 0 4 _aDNA Methylation
650 0 4 _aDiscoidin Domain Receptor 1
_xgenetics
650 0 4 _aDrug Resistance, Neoplasm
650 0 4 _aDrug Synergism
650 0 4 _aEnhancer Elements, Genetic
650 0 4 _aEpigenesis, Genetic
650 0 4 _aFemale
650 0 4 _aHeterocyclic Compounds, 4 or More Rings
_xpharmacology
650 0 4 _aHumans
650 0 4 _aMAP Kinase Kinase 1
_xantagonists & inhibitors
650 0 4 _aMAP Kinase Kinase 2
_xantagonists & inhibitors
650 0 4 _aMice, Inbred BALB C
650 0 4 _aMice, SCID
650 0 4 _aMolecular Targeted Therapy
650 0 4 _aNuclear Proteins
_xantagonists & inhibitors
650 0 4 _aPositive Transcriptional Elongation Factor B
_xantagonists & inhibitors
650 0 4 _aPyridones
_xpharmacology
650 0 4 _aPyrimidinones
_xpharmacology
650 0 4 _aRNA Interference
650 0 4 _aTranscription Factors
_xantagonists & inhibitors
650 0 4 _aTriazoles
_xpharmacology
650 0 4 _aTriple Negative Breast Neoplasms
_xdrug therapy
650 0 4 _aXenograft Model Antitumor Assays
700 1 _aBevill, Samantha M
700 1 _aGoulet, Daniel R
700 1 _aStuhlmiller, Timothy J
700 1 _aBeltran, Adriana S
700 1 _aOlivares-Quintero, Jose F
700 1 _aSingh, Darshan
700 1 _aSciaky, Noah
700 1 _aParker, Joel S
700 1 _aRashid, Naim U
700 1 _aChen, Xin
700 1 _aDuncan, James S
700 1 _aWhittle, Martin C
700 1 _aAngus, Steven P
700 1 _aVelarde, Sara Hanna
700 1 _aGolitz, Brian T
700 1 _aHe, Xiaping
700 1 _aSantos, Charlene
700 1 _aDarr, David B
700 1 _aGallagher, Kristalyn
700 1 _aGraves, Lee M
700 1 _aPerou, Charles M
700 1 _aCarey, Lisa A
700 1 _aEarp, H Shelton
700 1 _aJohnson, Gary L
773 0 _tCancer discovery
_gvol. 7
_gno. 3
_gp. 302-321
856 4 0 _uhttps://doi.org/10.1158/2159-8290.CD-16-0653
_zAvailable from publisher's website
999 _c26804727
_d26804727