000 02212 a2200613 4500
005 20250517133925.0
264 0 _c20180424
008 201804s 0 0 eng d
022 _a1091-6490
024 7 _a10.1073/pnas.1618627114
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aKang, Seong Su
245 0 0 _aα-Synuclein binds and sequesters PIKE-L into Lewy bodies, triggering dopaminergic cell death via AMPK hyperactivation.
_h[electronic resource]
260 _bProceedings of the National Academy of Sciences of the United States of America
_c01 2017
300 _a1183-1188 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, Non-U.S. Gov't
650 0 4 _a1-Methyl-4-phenylpyridinium
_xtoxicity
650 0 4 _aAdenylate Kinase
_xmetabolism
650 0 4 _aAged
650 0 4 _aAged, 80 and over
650 0 4 _aAnimals
650 0 4 _aCell Death
650 0 4 _aDopaminergic Neurons
_xmetabolism
650 0 4 _aEnzyme Activation
650 0 4 _aGTP Phosphohydrolases
_xdeficiency
650 0 4 _aGTP-Binding Proteins
_xchemistry
650 0 4 _aGTPase-Activating Proteins
_xchemistry
650 0 4 _aHumans
650 0 4 _aLewy Bodies
_xmetabolism
650 0 4 _aMPTP Poisoning
_xmetabolism
650 0 4 _aMice
650 0 4 _aMice, Inbred C57BL
650 0 4 _aMice, Knockout
650 0 4 _aNerve Tissue Proteins
_xdeficiency
650 0 4 _aPhosphorylation
650 0 4 _aPleckstrin Homology Domains
650 0 4 _aProtein Aggregation, Pathological
650 0 4 _aProtein Binding
650 0 4 _aProtein Interaction Mapping
650 0 4 _aProtein Processing, Post-Translational
650 0 4 _aProto-Oncogene Proteins c-fyn
_xdeficiency
650 0 4 _aalpha-Synuclein
_xmetabolism
700 1 _aZhang, Zhentao
700 1 _aLiu, Xia
700 1 _aManfredsson, Fredric P
700 1 _aHe, Li
700 1 _aIuvone, P Michael
700 1 _aCao, Xuebing
700 1 _aSun, Yi E
700 1 _aJin, Lingjing
700 1 _aYe, Keqiang
773 0 _tProceedings of the National Academy of Sciences of the United States of America
_gvol. 114
_gno. 5
_gp. 1183-1188
856 4 0 _uhttps://doi.org/10.1073/pnas.1618627114
_zAvailable from publisher's website
999 _c26793005
_d26793005