000 02212 a2200709 4500
005 20250517123559.0
264 0 _c20170321
008 201703s 0 0 eng d
022 _a1476-4687
024 7 _a10.1038/nature20134
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aDever, Daniel P
245 0 0 _aCRISPR/Cas9 β-globin gene targeting in human haematopoietic stem cells.
_h[electronic resource]
260 _bNature
_c11 2016
300 _a384-389 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
650 0 4 _aAlleles
650 0 4 _aAnemia, Sickle Cell
_xgenetics
650 0 4 _aAnimals
650 0 4 _aAntigens, CD34
_xmetabolism
650 0 4 _aCRISPR-Associated Proteins
_xmetabolism
650 0 4 _aCRISPR-Cas Systems
_xgenetics
650 0 4 _aCell Differentiation
650 0 4 _aCell Lineage
650 0 4 _aCell Separation
650 0 4 _aDependovirus
_xgenetics
650 0 4 _aErythrocytes
650 0 4 _aFemale
650 0 4 _aFlow Cytometry
650 0 4 _aGene Editing
_xmethods
650 0 4 _aGene Targeting
650 0 4 _aGenes, Reporter
650 0 4 _aGenetic Therapy
_xmethods
650 0 4 _aHematopoietic Stem Cells
_xmetabolism
650 0 4 _aHomologous Recombination
650 0 4 _aHumans
650 0 4 _aMagnets
650 0 4 _aMice, Inbred NOD
650 0 4 _aMice, SCID
650 0 4 _aMicrospheres
650 0 4 _aMutation
650 0 4 _aRNA, Messenger
_xbiosynthesis
650 0 4 _abeta-Globins
_xgenetics
650 0 4 _abeta-Thalassemia
_xgenetics
700 1 _aBak, Rasmus O
700 1 _aReinisch, Andreas
700 1 _aCamarena, Joab
700 1 _aWashington, Gabriel
700 1 _aNicolas, Carmencita E
700 1 _aPavel-Dinu, Mara
700 1 _aSaxena, Nivi
700 1 _aWilkens, Alec B
700 1 _aMantri, Sruthi
700 1 _aUchida, Nobuko
700 1 _aHendel, Ayal
700 1 _aNarla, Anupama
700 1 _aMajeti, Ravindra
700 1 _aWeinberg, Kenneth I
700 1 _aPorteus, Matthew H
773 0 _tNature
_gvol. 539
_gno. 7629
_gp. 384-389
856 4 0 _uhttps://doi.org/10.1038/nature20134
_zAvailable from publisher's website
999 _c26583729
_d26583729