000 02366 a2200709 4500
005 20250517123015.0
264 0 _c20170321
008 201703s 0 0 eng d
022 _a1476-4687
024 7 _a10.1038/nature20132
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aKottakis, Filippos
245 0 0 _aLKB1 loss links serine metabolism to DNA methylation and tumorigenesis.
_h[electronic resource]
260 _bNature
_c11 2016
300 _a390-395 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
650 0 4 _aAMP-Activated Protein Kinase Kinases
650 0 4 _aAMP-Activated Protein Kinases
650 0 4 _aAnimals
650 0 4 _aCell Culture Techniques
650 0 4 _aCell Line, Tumor
650 0 4 _aCell Transformation, Neoplastic
650 0 4 _aChromatin
_xgenetics
650 0 4 _aDNA (Cytosine-5-)-Methyltransferases
_xmetabolism
650 0 4 _aDNA Methylation
_xdrug effects
650 0 4 _aEnzyme Inhibitors
_xpharmacology
650 0 4 _aEpithelial Cells
_xmetabolism
650 0 4 _aGene Silencing
650 0 4 _aGenes, Tumor Suppressor
650 0 4 _aGlycine
_xmetabolism
650 0 4 _aGlycolysis
650 0 4 _aHumans
650 0 4 _aMice
650 0 4 _aPancreatic Ducts
_xcytology
650 0 4 _aProtein Serine-Threonine Kinases
_xdeficiency
650 0 4 _aProto-Oncogene Proteins p21(ras)
_xgenetics
650 0 4 _aRetroelements
_xgenetics
650 0 4 _aS-Adenosylmethionine
_xmetabolism
650 0 4 _aSerine
_xbiosynthesis
650 0 4 _aTOR Serine-Threonine Kinases
_xmetabolism
650 0 4 _aTransaminases
_xmetabolism
700 1 _aNicolay, Brandon N
700 1 _aRoumane, Ahlima
700 1 _aKarnik, Rahul
700 1 _aGu, Hongcang
700 1 _aNagle, Julia M
700 1 _aBoukhali, Myriam
700 1 _aHayward, Michele C
700 1 _aLi, Yvonne Y
700 1 _aChen, Ting
700 1 _aLiesa, Marc
700 1 _aHammerman, Peter S
700 1 _aWong, Kwok Kin
700 1 _aHayes, D Neil
700 1 _aShirihai, Orian S
700 1 _aDyson, Nicholas J
700 1 _aHaas, Wilhelm
700 1 _aMeissner, Alexander
700 1 _aBardeesy, Nabeel
773 0 _tNature
_gvol. 539
_gno. 7629
_gp. 390-395
856 4 0 _uhttps://doi.org/10.1038/nature20132
_zAvailable from publisher's website
999 _c26565683
_d26565683