000 02212 a2200589 4500
005 20250517122844.0
264 0 _c20170808
008 201708s 0 0 eng d
022 _a1872-7980
024 7 _a10.1016/j.canlet.2016.10.025
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aCholewa, Brian D
245 0 0 _aSmall molecule inhibition of polo-like kinase 1 by volasertib (BI 6727) causes significant melanoma growth delay and regression in vivo.
_h[electronic resource]
260 _bCancer letters
_c01 2017
300 _a179-187 p.
_bdigital
500 _aPublication Type: Journal Article
650 0 4 _aAnimals
650 0 4 _aAntineoplastic Agents
_xpharmacology
650 0 4 _aApoptosis
_xdrug effects
650 0 4 _aCaspase 3
_xmetabolism
650 0 4 _aCell Cycle Proteins
_xantagonists & inhibitors
650 0 4 _aCell Line, Tumor
650 0 4 _aCell Proliferation
_xdrug effects
650 0 4 _aCyclin-Dependent Kinase Inhibitor p21
_xmetabolism
650 0 4 _aDose-Response Relationship, Drug
650 0 4 _aG2 Phase Cell Cycle Checkpoints
_xdrug effects
650 0 4 _aHumans
650 0 4 _aKi-67 Antigen
_xmetabolism
650 0 4 _aMelanoma
_xdrug therapy
650 0 4 _aMice, Nude
650 0 4 _aMolecular Targeted Therapy
650 0 4 _aMutation
650 0 4 _aProtein Kinase Inhibitors
_xpharmacology
650 0 4 _aProtein Serine-Threonine Kinases
_xantagonists & inhibitors
650 0 4 _aProto-Oncogene Proteins
_xantagonists & inhibitors
650 0 4 _aProto-Oncogene Proteins B-raf
_xgenetics
650 0 4 _aPteridines
_xpharmacology
650 0 4 _aS Phase Cell Cycle Checkpoints
_xdrug effects
650 0 4 _aSignal Transduction
_xdrug effects
650 0 4 _aSkin Neoplasms
_xdrug therapy
650 0 4 _aTime Factors
650 0 4 _aTumor Burden
_xdrug effects
650 0 4 _aTumor Suppressor Protein p53
_xmetabolism
650 0 4 _aXenograft Model Antitumor Assays
650 0 4 _aPolo-Like Kinase 1
700 1 _aNdiaye, Mary A
700 1 _aHuang, Wei
700 1 _aLiu, Xiaoqi
700 1 _aAhmad, Nihal
773 0 _tCancer letters
_gvol. 385
_gp. 179-187
856 4 0 _uhttps://doi.org/10.1016/j.canlet.2016.10.025
_zAvailable from publisher's website
999 _c26560429
_d26560429