000 02779 a2200853 4500
005 20250517122813.0
264 0 _c20170310
008 201703s 0 0 eng d
022 _a1554-8937
024 7 _a10.1021/acschembio.6b00677
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aTelliez, Jean-Baptiste
245 0 0 _aDiscovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition.
_h[electronic resource]
260 _bACS chemical biology
_c12 2016
300 _a3442-3451 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't
650 0 4 _aAnimals
650 0 4 _aArthritis, Experimental
_xdrug therapy
650 0 4 _aDisease Models, Animal
650 0 4 _aDrug Discovery
650 0 4 _aEncephalomyelitis, Autoimmune, Experimental
_xdrug therapy
650 0 4 _aHumans
650 0 4 _aInterleukin-10
_ximmunology
650 0 4 _aInterleukin-1beta
_ximmunology
650 0 4 _aJanus Kinase 1
_xantagonists & inhibitors
650 0 4 _aJanus Kinase 3
_xantagonists & inhibitors
650 0 4 _aMacrophages
_xcytology
650 0 4 _aMice
650 0 4 _aModels, Molecular
650 0 4 _aProtein Kinase Inhibitors
_xpharmacokinetics
650 0 4 _aPyrimidines
_xpharmacokinetics
650 0 4 _aPyrroles
_xpharmacokinetics
650 0 4 _aRats
650 0 4 _aTh1 Cells
_xcytology
650 0 4 _aTh17 Cells
_xcytology
650 0 4 _aTumor Necrosis Factor-alpha
_ximmunology
700 1 _aDowty, Martin E
700 1 _aWang, Lu
700 1 _aJussif, Jason
700 1 _aLin, Tsung
700 1 _aLi, Li
700 1 _aMoy, Erick
700 1 _aBalbo, Paul
700 1 _aLi, Wei
700 1 _aZhao, Yajuan
700 1 _aCrouse, Kimberly
700 1 _aDickinson, Caitlyn
700 1 _aSymanowicz, Peter
700 1 _aHegen, Martin
700 1 _aBanker, Mary Ellen
700 1 _aVincent, Fabien
700 1 _aUnwalla, Ray
700 1 _aLiang, Sidney
700 1 _aGilbert, Adam M
700 1 _aBrown, Matthew F
700 1 _aHayward, Matthew
700 1 _aMontgomery, Justin
700 1 _aYang, Xin
700 1 _aBauman, Jonathan
700 1 _aTrujillo, John I
700 1 _aCasimiro-Garcia, Agustin
700 1 _aVajdos, Felix F
700 1 _aLeung, Louis
700 1 _aGeoghegan, Kieran F
700 1 _aQuazi, Amira
700 1 _aXuan, Dejun
700 1 _aJones, Lyn
700 1 _aHett, Erik
700 1 _aWright, Katherine
700 1 _aClark, James D
700 1 _aThorarensen, Atli
773 0 _tACS chemical biology
_gvol. 11
_gno. 12
_gp. 3442-3451
856 4 0 _uhttps://doi.org/10.1021/acschembio.6b00677
_zAvailable from publisher's website
999 _c26558679
_d26558679