| 000 | 01862 a2200541 4500 | ||
|---|---|---|---|
| 005 | 20250517122629.0 | ||
| 264 | 0 | _c20180221 | |
| 008 | 201802s 0 0 eng d | ||
| 022 | _a1521-009X | ||
| 024 | 7 |
_a10.1124/dmd.116.072983 _2doi |
|
| 040 |
_aNLM _beng _cNLM |
||
| 100 | 1 | _aLeung, Louis | |
| 245 | 0 | 0 |
_aClearance Prediction of Targeted Covalent Inhibitors by In Vitro-In Vivo Extrapolation of Hepatic and Extrahepatic Clearance Mechanisms. _h[electronic resource] |
| 260 |
_bDrug metabolism and disposition: the biological fate of chemicals _c01 2017 |
||
| 300 |
_a1-7 p. _bdigital |
||
| 500 | _aPublication Type: Journal Article | ||
| 650 | 0 | 4 | _aAlgorithms |
| 650 | 0 | 4 | _aAnimals |
| 650 | 0 | 4 | _aDrug Evaluation, Preclinical |
| 650 | 0 | 4 |
_aGlutathione _xmetabolism |
| 650 | 0 | 4 |
_aHepatocytes _xmetabolism |
| 650 | 0 | 4 | _aHumans |
| 650 | 0 | 4 | _aIn Vitro Techniques |
| 650 | 0 | 4 | _aMale |
| 650 | 0 | 4 | _aMetabolic Clearance Rate |
| 650 | 0 | 4 | _aMice, Inbred C57BL |
| 650 | 0 | 4 |
_aMicrosomes, Liver _xmetabolism |
| 650 | 0 | 4 | _aModels, Biological |
| 650 | 0 | 4 |
_aPharmaceutical Preparations _xblood |
| 650 | 0 | 4 |
_aPlasma _xmetabolism |
| 650 | 0 | 4 | _aPredictive Value of Tests |
| 650 | 0 | 4 | _aProtein Binding |
| 650 | 0 | 4 |
_aProtein Kinase Inhibitors _xblood |
| 650 | 0 | 4 | _aRats |
| 650 | 0 | 4 | _aRats, Sprague-Dawley |
| 650 | 0 | 4 | _aSpecies Specificity |
| 700 | 1 | _aYang, Xin | |
| 700 | 1 | _aStrelevitz, Timothy J | |
| 700 | 1 | _aMontgomery, Justin | |
| 700 | 1 | _aBrown, Matthew F | |
| 700 | 1 | _aZientek, Michael A | |
| 700 | 1 | _aBanfield, Christopher | |
| 700 | 1 | _aGilbert, Adam M | |
| 700 | 1 | _aThorarensen, Atli | |
| 700 | 1 | _aDowty, Martin E | |
| 773 | 0 |
_tDrug metabolism and disposition: the biological fate of chemicals _gvol. 45 _gno. 1 _gp. 1-7 |
|
| 856 | 4 | 0 |
_uhttps://doi.org/10.1124/dmd.116.072983 _zAvailable from publisher's website |
| 999 |
_c26552875 _d26552875 |
||