000			02035 a2200541 4500
005			20250517102907.0
264		0	_c20170609
008			201706s 0 0 eng d
022			_a1520-4804
024	7		_a10.1021/acs.jmedchem.6b00562 _2doi
040			_aNLM _beng _cNLM
100	1		_aPisani, Leonardo
245	0	0	_aExploring Basic Tail Modifications of Coumarin-Based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-Soluble, Brain-Permeant Neuroprotective Multitarget Agents. _h[electronic resource]
260			_bJournal of medicinal chemistry _c07 2016
300			_a6791-806 p. _bdigital
500			_aPublication Type: Journal Article; Research Support, Non-U.S. Gov't
650	0	4	_aAcetylcholinesterase _xmetabolism
650	0	4	_aAnimals
650	0	4	_aCell Line, Tumor
650	0	4	_aCell Survival _xdrug effects
650	0	4	_aCholinesterase Inhibitors _xchemical synthesis
650	0	4	_aCoumarins _xchemical synthesis
650	0	4	_aDogs
650	0	4	_aDose-Response Relationship, Drug
650	0	4	_aHumans
650	0	4	_aMadin Darby Canine Kidney Cells
650	0	4	_aMolecular Structure
650	0	4	_aMonoamine Oxidase _xmetabolism
650	0	4	_aMonoamine Oxidase Inhibitors _xchemical synthesis
650	0	4	_aNeuroprotective Agents _xchemical synthesis
650	0	4	_aOxidative Stress _xdrug effects
650	0	4	_aSolubility
650	0	4	_aStructure-Activity Relationship
650	0	4	_aWater _xchemistry
700	1		_aFarina, Roberta
700	1		_aCatto, Marco
700	1		_aIacobazzi, Rosa Maria
700	1		_aNicolotti, Orazio
700	1		_aCellamare, Saverio
700	1		_aMangiatordi, Giuseppe Felice
700	1		_aDenora, Nunzio
700	1		_aSoto-Otero, Ramon
700	1		_aSiragusa, Lydia
700	1		_aAltomare, Cosimo Damiano
700	1		_aCarotti, Angelo
773	0		_tJournal of medicinal chemistry _gvol. 59 _gno. 14 _gp. 6791-806
856	4	0	_uhttps://doi.org/10.1021/acs.jmedchem.6b00562 _zAvailable from publisher's website
999			_c26164450 _d26164450