000 02342 a2200697 4500
005 20250517095404.0
264 0 _c20170807
008 201708s 0 0 eng d
022 _a1546-170X
024 7 _a10.1038/nm.4107
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aDauch, Daniel
245 0 0 _aA MYC-aurora kinase A protein complex represents an actionable drug target in p53-altered liver cancer.
_h[electronic resource]
260 _bNature medicine
_c07 2016
300 _a744-53 p.
_bdigital
500 _aPublication Type: Journal Article
650 0 4 _aAnimals
650 0 4 _aAurora Kinase A
_xantagonists & inhibitors
650 0 4 _aAzepines
_xpharmacology
650 0 4 _aCarcinoma, Hepatocellular
_xdrug therapy
650 0 4 _aCell Cycle Checkpoints
650 0 4 _aCyclin-Dependent Kinase Inhibitor p16
_xgenetics
650 0 4 _aGene Deletion
650 0 4 _aHepatocytes
_xmetabolism
650 0 4 _aHumans
650 0 4 _aLiver Neoplasms
_xdrug therapy
650 0 4 _aLiver Neoplasms, Experimental
_xdrug therapy
650 0 4 _aMice
650 0 4 _aMice, Knockout
650 0 4 _aMolecular Targeted Therapy
650 0 4 _aMonomeric GTP-Binding Proteins
_xgenetics
650 0 4 _aMutation
650 0 4 _aOncogene Protein p21(ras)
_xmetabolism
650 0 4 _aPhenylurea Compounds
_xpharmacology
650 0 4 _aProtein Kinase Inhibitors
_xpharmacology
650 0 4 _aProto-Oncogene Proteins c-myc
_xmetabolism
650 0 4 _aPyrimidines
_xpharmacology
650 0 4 _aRNA, Small Interfering
650 0 4 _aTumor Suppressor Protein p53
_xgenetics
650 0 4 _aXenograft Model Antitumor Assays
700 1 _aRudalska, Ramona
700 1 _aCossa, Giacomo
700 1 _aNault, Jean-Charles
700 1 _aKang, Tae-Won
700 1 _aWuestefeld, Torsten
700 1 _aHohmeyer, Anja
700 1 _aImbeaud, Sandrine
700 1 _aYevsa, Tetyana
700 1 _aHoenicke, Lisa
700 1 _aPantsar, Tatu
700 1 _aBozko, Przemyslaw
700 1 _aMalek, Nisar P
700 1 _aLongerich, Thomas
700 1 _aLaufer, Stefan
700 1 _aPoso, Antti
700 1 _aZucman-Rossi, Jessica
700 1 _aEilers, Martin
700 1 _aZender, Lars
773 0 _tNature medicine
_gvol. 22
_gno. 7
_gp. 744-53
856 4 0 _uhttps://doi.org/10.1038/nm.4107
_zAvailable from publisher's website
999 _c26049295
_d26049295