000 01360 a2200361 4500
005 20250517094918.0
264 0 _c20180102
008 201801s 0 0 eng d
022 _a1463-9084
024 7 _a10.1039/c5cp05521k
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aNerattini, Francesca
245 0 0 _aII. Dissociation free energies in drug-receptor systems via nonequilibrium alchemical simulations: application to the FK506-related immunophilin ligands.
_h[electronic resource]
260 _bPhysical chemistry chemical physics : PCCP
_c06 2016
300 _a15005-18 p.
_bdigital
500 _aPublication Type: Journal Article
650 0 4 _aCalcineurin Inhibitors
_xmetabolism
650 0 4 _aDrug Discovery
650 0 4 _aHumans
650 0 4 _aImmunosuppressive Agents
_xmetabolism
650 0 4 _aLigands
650 0 4 _aMolecular Dynamics Simulation
650 0 4 _aPoint Mutation
650 0 4 _aProtein Binding
650 0 4 _aProtein Conformation
650 0 4 _aTacrolimus
_xmetabolism
650 0 4 _aTacrolimus Binding Protein 1A
_xantagonists & inhibitors
650 0 4 _aThermodynamics
700 1 _aChelli, Riccardo
700 1 _aProcacci, Piero
773 0 _tPhysical chemistry chemical physics : PCCP
_gvol. 18
_gno. 22
_gp. 15005-18
856 4 0 _uhttps://doi.org/10.1039/c5cp05521k
_zAvailable from publisher's website
999 _c26032834
_d26032834