000 01410 a2200385 4500
005 20250517092201.0
264 0 _c20161014
008 201610s 0 0 eng d
022 _a1741-7007
024 7 _a10.1186/s12915-016-0255-4
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aMaric-Biresev, Jelena
245 0 0 _aLoss of the interferon-γ-inducible regulatory immunity-related GTPase (IRG), Irgm1, causes activation of effector IRG proteins on lysosomes, damaging lysosomal function and predicting the dramatic susceptibility of Irgm1-deficient mice to infection.
_h[electronic resource]
260 _bBMC biology
_cApr 2016
300 _a33 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, Non-U.S. Gov't
650 0 4 _aAnimals
650 0 4 _aAutophagy
650 0 4 _aCell Line
650 0 4 _aGTP Phosphohydrolases
_xanalysis
650 0 4 _aGTP-Binding Proteins
_xanalysis
650 0 4 _aGene Deletion
650 0 4 _aImmunity, Innate
650 0 4 _aInfections
_xgenetics
650 0 4 _aLysosomes
_ximmunology
650 0 4 _aMice
650 0 4 _aMice, Inbred C57BL
700 1 _aHunn, Julia P
700 1 _aKrut, Oleg
700 1 _aHelms, J Bernd
700 1 _aMartens, Sascha
700 1 _aHoward, Jonathan C
773 0 _tBMC biology
_gvol. 14
_gp. 33
856 4 0 _uhttps://doi.org/10.1186/s12915-016-0255-4
_zAvailable from publisher's website
999 _c25943924
_d25943924