000 01423 a2200349 4500
005 20250517051758.0
264 0 _c20160104
008 201601s 0 0 eng d
022 _a1521-0103
024 7 _a10.1124/jpet.115.224899
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aPage, Kevin R
245 0 0 _aTemporal pharmacokinetic/pharmacodynamic interaction between human CD3ε antigen-targeted monoclonal antibody otelixizumab and CD3ε binding and expression in human peripheral blood mononuclear cell static culture.
_h[electronic resource]
260 _bThe Journal of pharmacology and experimental therapeutics
_cNov 2015
300 _a199-205 p.
_bdigital
500 _aPublication Type: Journal Article
650 0 4 _aAntibodies, Monoclonal, Humanized
_xpharmacokinetics
650 0 4 _aCD3 Complex
_xblood
650 0 4 _aCells, Cultured
650 0 4 _aHumans
650 0 4 _aLeukocytes, Mononuclear
_xdrug effects
650 0 4 _aProtein Binding
650 0 4 _aReceptors, Antigen, T-Cell
_xmetabolism
650 0 4 _aTime Factors
700 1 _aMezzalana, Enrica
700 1 _aMacDonald, Alexander J
700 1 _aZamuner, Stefano
700 1 _aDe Nicolao, Giuseppe
700 1 _avan Maurik, Andre
773 0 _tThe Journal of pharmacology and experimental therapeutics
_gvol. 355
_gno. 2
_gp. 199-205
856 4 0 _uhttps://doi.org/10.1124/jpet.115.224899
_zAvailable from publisher's website
999 _c25233646
_d25233646