000 01821 a2200481 4500
005 20250517051429.0
264 0 _c20160801
008 201608s 0 0 eng d
022 _a1573-6768
024 7 _a10.1007/s10522-015-9605-9
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aSong, Tuzz-Ying
245 0 0 _aA Nampt inhibitor FK866 mimics vitamin B3 deficiency by causing senescence of human fibroblastic Hs68 cells via attenuation of NAD(+)-SIRT1 signaling.
_h[electronic resource]
260 _bBiogerontology
_cDec 2015
300 _a789-800 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, Non-U.S. Gov't
650 0 4 _aAMP-Activated Protein Kinases
_xmetabolism
650 0 4 _aAcrylamides
_xpharmacology
650 0 4 _aCell Line
650 0 4 _aCell Proliferation
_xdrug effects
650 0 4 _aCellular Senescence
_xdrug effects
650 0 4 _aCytokines
_xantagonists & inhibitors
650 0 4 _aEnzyme Inhibitors
_xpharmacology
650 0 4 _aFibroblasts
_xcytology
650 0 4 _aGlutathione
_xmetabolism
650 0 4 _aHumans
650 0 4 _aNAD
_xmetabolism
650 0 4 _aNADP
_xmetabolism
650 0 4 _aNiacin
_xpharmacology
650 0 4 _aNiacinamide
_xdeficiency
650 0 4 _aNicotinamide Phosphoribosyltransferase
_xantagonists & inhibitors
650 0 4 _aPiperidines
_xpharmacology
650 0 4 _aSignal Transduction
_xdrug effects
650 0 4 _aSirtuin 1
_xmetabolism
650 0 4 _aTOR Serine-Threonine Kinases
_xmetabolism
650 0 4 _aTumor Suppressor Protein p53
_xmetabolism
700 1 _aYeh, Shu-Lan
700 1 _aHu, Miao-Lin
700 1 _aChen, Mei-Yau
700 1 _aYang, Nae-Cherng
773 0 _tBiogerontology
_gvol. 16
_gno. 6
_gp. 789-800
856 4 0 _uhttps://doi.org/10.1007/s10522-015-9605-9
_zAvailable from publisher's website
999 _c25222876
_d25222876