000 02493 a2200769 4500
005 20250517045639.0
264 0 _c20151214
008 201512s 0 0 eng d
022 _a1520-4804
024 7 _a10.1021/acs.jmedchem.5b01082
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aEngel, Julian
245 0 0 _aTargeting Drug Resistance in EGFR with Covalent Inhibitors: A Structure-Based Design Approach.
_h[electronic resource]
260 _bJournal of medicinal chemistry
_cSep 2015
300 _a6844-63 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, Non-U.S. Gov't
650 0 4 _aAntineoplastic Agents
_xchemistry
650 0 4 _aCarcinoma, Non-Small-Cell Lung
650 0 4 _aCell Line, Tumor
650 0 4 _aCell Membrane Permeability
650 0 4 _aCrystallography, X-Ray
650 0 4 _aDatabases, Chemical
650 0 4 _aDrug Design
650 0 4 _aDrug Resistance, Neoplasm
650 0 4 _aErbB Receptors
_xantagonists & inhibitors
650 0 4 _aHumans
650 0 4 _aKinetics
650 0 4 _aLung Neoplasms
650 0 4 _aModels, Molecular
650 0 4 _aMolecular Conformation
650 0 4 _aMutation
650 0 4 _aPyrazoles
_xchemistry
650 0 4 _aPyrimidines
_xchemistry
650 0 4 _aQuinazolines
_xchemistry
650 0 4 _aSmall Molecule Libraries
650 0 4 _aSolubility
650 0 4 _aStructure-Activity Relationship
650 0 4 _asrc-Family Kinases
_xchemistry
700 1 _aRichters, André
700 1 _aGetlik, Matthäus
700 1 _aTomassi, Stefano
700 1 _aKeul, Marina
700 1 _aTermathe, Martin
700 1 _aLategahn, Jonas
700 1 _aBecker, Christian
700 1 _aMayer-Wrangowski, Svenja
700 1 _aGrütter, Christian
700 1 _aUhlenbrock, Niklas
700 1 _aKrüll, Jasmin
700 1 _aSchaumann, Niklas
700 1 _aEppmann, Simone
700 1 _aKibies, Patrick
700 1 _aHoffgaard, Franziska
700 1 _aHeil, Jochen
700 1 _aMenninger, Sascha
700 1 _aOrtiz-Cuaran, Sandra
700 1 _aHeuckmann, Johannes M
700 1 _aTinnefeld, Verena
700 1 _aZahedi, René P
700 1 _aSos, Martin L
700 1 _aSchultz-Fademrecht, Carsten
700 1 _aThomas, Roman K
700 1 _aKast, Stefan M
700 1 _aRauh, Daniel
773 0 _tJournal of medicinal chemistry
_gvol. 58
_gno. 17
_gp. 6844-63
856 4 0 _uhttps://doi.org/10.1021/acs.jmedchem.5b01082
_zAvailable from publisher's website
999 _c25170804
_d25170804