000			01894 a2200529 4500
005			20250517042611.0
264		0	_c20160329
008			201603s 0 0 eng d
022			_a2374-2445
024	7		_a10.1001/jamaoncol.2015.1066 _2doi
040			_aNLM _beng _cNLM
100	1		_aYu, Helena A
245	0	0	_aAcquired Resistance of EGFR-Mutant Lung Cancer to a T790M-Specific EGFR Inhibitor: Emergence of a Third Mutation (C797S) in the EGFR Tyrosine Kinase Domain. _h[electronic resource]
260			_bJAMA oncology _cOct 2015
300			_a982-4 p. _bdigital
500			_aPublication Type: Case Reports; Letter; Research Support, N.I.H., Extramural
650	0	4	_aAdenocarcinoma _xdrug therapy
650	0	4	_aAdenocarcinoma of Lung
650	0	4	_aAged
650	0	4	_aAntineoplastic Agents _xtherapeutic use
650	0	4	_aBiomarkers, Tumor _xantagonists & inhibitors
650	0	4	_aClinical Trials, Phase I as Topic
650	0	4	_aDNA Mutational Analysis
650	0	4	_aDrug Resistance, Neoplasm _xgenetics
650	0	4	_aDrug Substitution
650	0	4	_aErbB Receptors _xantagonists & inhibitors
650	0	4	_aFemale
650	0	4	_aGenetic Predisposition to Disease
650	0	4	_aHumans
650	0	4	_aLung Neoplasms _xdrug therapy
650	0	4	_aMiddle Aged
650	0	4	_aMolecular Targeted Therapy
650	0	4	_aMutation
650	0	4	_aPhenotype
650	0	4	_aProtein Kinase Inhibitors _xtherapeutic use
650	0	4	_aProtein Structure, Tertiary
650	0	4	_aTime Factors
650	0	4	_aTreatment Outcome
700	1		_aTian, Shaozhou K
700	1		_aDrilon, Alexander E
700	1		_aBorsu, Laetitia
700	1		_aRiely, Gregory J
700	1		_aArcila, Maria E
700	1		_aLadanyi, Marc
773	0		_tJAMA oncology _gvol. 1 _gno. 7 _gp. 982-4
856	4	0	_uhttps://doi.org/10.1001/jamaoncol.2015.1066 _zAvailable from publisher's website
999			_c25080674 _d25080674