000			01954 a2200553 4500
005			20250517040400.0
264		0	_c20151012
008			201510s 0 0 eng d
022			_a1520-4804
024	7		_a10.1021/acs.jmedchem.5b00599 _2doi
040			_aNLM _beng _cNLM
100	1		_aFarina, Roberta
245	0	0	_aStructure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases. _h[electronic resource]
260			_bJournal of medicinal chemistry _cJul 2015
300			_a5561-78 p. _bdigital
500			_aPublication Type: Journal Article; Research Support, Non-U.S. Gov't
650	0	4	_aAnimals
650	0	4	_aBlood-Brain Barrier _xmetabolism
650	0	4	_aCholinesterase Inhibitors _xchemistry
650	0	4	_aCholinesterases _xchemistry
650	0	4	_aCoumarins _xchemistry
650	0	4	_aDogs
650	0	4	_aDrug Design
650	0	4	_aHumans
650	0	4	_aInhibitory Concentration 50
650	0	4	_aMadin Darby Canine Kidney Cells
650	0	4	_aMolecular Docking Simulation
650	0	4	_aMonoamine Oxidase _xchemistry
650	0	4	_aMonoamine Oxidase Inhibitors _xchemistry
650	0	4	_aPermeability
650	0	4	_aProtein Conformation
650	0	4	_aRats
650	0	4	_aStructure-Activity Relationship
700	1		_aPisani, Leonardo
700	1		_aCatto, Marco
700	1		_aNicolotti, Orazio
700	1		_aGadaleta, Domenico
700	1		_aDenora, Nunzio
700	1		_aSoto-Otero, Ramon
700	1		_aMendez-Alvarez, Estefania
700	1		_aPassos, Carolina S
700	1		_aMuncipinto, Giovanni
700	1		_aAltomare, Cosimo D
700	1		_aNurisso, Alessandra
700	1		_aCarrupt, Pierre-Alain
700	1		_aCarotti, Angelo
773	0		_tJournal of medicinal chemistry _gvol. 58 _gno. 14 _gp. 5561-78
856	4	0	_uhttps://doi.org/10.1021/acs.jmedchem.5b00599 _zAvailable from publisher's website
999			_c25013409 _d25013409