000			01953 a2200529 4500
005			20250517033356.0
264		0	_c20150707
008			201507s 0 0 eng d
022			_a1095-9203
024	7		_a10.1126/science.aab1433 _2doi
040			_aNLM _beng _cNLM
100	1		_aWinter, Georg E
245	0	0	_aDRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation. _h[electronic resource]
260			_bScience (New York, N.Y.) _cJun 2015
300			_a1376-81 p. _bdigital
500			_aPublication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
650	0	4	_aAdaptor Proteins, Signal Transducing
650	0	4	_aAnimals
650	0	4	_aAzepines _xchemistry
650	0	4	_aCell Cycle Proteins
650	0	4	_aCell Line, Tumor
650	0	4	_aCrystallography, X-Ray
650	0	4	_aDisease Models, Animal
650	0	4	_aDrug Design
650	0	4	_aLeukemia, Promyelocytic, Acute _xdrug therapy
650	0	4	_aLigands
650	0	4	_aMice
650	0	4	_aMolecular Targeted Therapy
650	0	4	_aNuclear Proteins _xantagonists & inhibitors
650	0	4	_aPeptide Hydrolases _xmetabolism
650	0	4	_aPhthalimides _xchemistry
650	0	4	_aProtein Stability _xdrug effects
650	0	4	_aProtein Structure, Tertiary
650	0	4	_aProteolysis _xdrug effects
650	0	4	_aTacrolimus Binding Protein 1A _xmetabolism
650	0	4	_aThalidomide _xanalogs & derivatives
650	0	4	_aTranscription Factors _xantagonists & inhibitors
650	0	4	_aUbiquitin-Protein Ligases _xmetabolism
700	1		_aBuckley, Dennis L
700	1		_aPaulk, Joshiawa
700	1		_aRoberts, Justin M
700	1		_aSouza, Amanda
700	1		_aDhe-Paganon, Sirano
700	1		_aBradner, James E
773	0		_tScience (New York, N.Y.) _gvol. 348 _gno. 6241 _gp. 1376-81
856	4	0	_uhttps://doi.org/10.1126/science.aab1433 _zAvailable from publisher's website
999			_c24924967 _d24924967