000			01979 a2200493 4500
005			20250517032002.0
264		0	_c20160202
008			201602s 0 0 eng d
022			_a1932-6203
024	7		_a10.1371/journal.pone.0125779 _2doi
040			_aNLM _beng _cNLM
100	1		_aTanaka, Ryoichi
245	0	0	_aMetformin Causes G1-Phase Arrest via Down-Regulation of MiR-221 and Enhances TRAIL Sensitivity through DR5 Up-Regulation in Pancreatic Cancer Cells. _h[electronic resource]
260			_bPloS one _c2015
300			_ae0125779 p. _bdigital
500			_aPublication Type: Journal Article; Research Support, Non-U.S. Gov't
650	0	4	_aAntineoplastic Agents _xtoxicity
650	0	4	_aApoptosis _xdrug effects
650	0	4	_aApoptosis Regulatory Proteins _xmetabolism
650	0	4	_aBcl-2-Like Protein 11
650	0	4	_aCell Line, Tumor
650	0	4	_aCell Proliferation _xdrug effects
650	0	4	_aCyclin-Dependent Kinase Inhibitor p27 _xmetabolism
650	0	4	_aDown-Regulation _xdrug effects
650	0	4	_aDrug Resistance, Neoplasm _xdrug effects
650	0	4	_aG1 Phase Cell Cycle Checkpoints _xdrug effects
650	0	4	_aHumans
650	0	4	_aMembrane Proteins _xmetabolism
650	0	4	_aMetformin _xtoxicity
650	0	4	_aMicroRNAs _xantagonists & inhibitors
650	0	4	_aOligonucleotides, Antisense _xmetabolism
650	0	4	_aPancreatic Neoplasms _xmetabolism
650	0	4	_aProto-Oncogene Proteins _xmetabolism
650	0	4	_aReceptors, TNF-Related Apoptosis-Inducing Ligand _xmetabolism
650	0	4	_aTNF-Related Apoptosis-Inducing Ligand _xtoxicity
650	0	4	_aTumor Suppressor Protein p53 _xgenetics
650	0	4	_aUp-Regulation _xdrug effects
700	1		_aTomosugi, Mitsuhiro
700	1		_aHorinaka, Mano
700	1		_aSowa, Yoshihiro
700	1		_aSakai, Toshiyuki
773	0		_tPloS one _gvol. 10 _gno. 5 _gp. e0125779
856	4	0	_uhttps://doi.org/10.1371/journal.pone.0125779 _zAvailable from publisher's website
999			_c24882785 _d24882785