000 01894 a2200577 4500
005 20250517030658.0
264 0 _c20160315
008 201603s 0 0 eng d
022 _a2041-1723
024 7 _a10.1038/ncomms7706
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aHiraoka, Kiriko
245 0 0 _aInhibition of KRAS codon 12 mutants using a novel DNA-alkylating pyrrole-imidazole polyamide conjugate.
_h[electronic resource]
260 _bNature communications
_cApr 2015
300 _a6706 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, Non-U.S. Gov't
650 0 4 _aAnimals
650 0 4 _aAntineoplastic Agents
_xchemical synthesis
650 0 4 _aApoptosis
_xdrug effects
650 0 4 _aCaco-2 Cells
650 0 4 _aCellular Senescence
_xdrug effects
650 0 4 _aDNA Damage
650 0 4 _aDrug Evaluation, Preclinical
650 0 4 _aFemale
650 0 4 _aHT29 Cells
650 0 4 _aHumans
650 0 4 _aImidazoles
_xchemical synthesis
650 0 4 _aMice, Nude
650 0 4 _aMutation
650 0 4 _aNeoplasms, Experimental
_xdrug therapy
650 0 4 _aNylons
_xchemical synthesis
650 0 4 _aProto-Oncogene Proteins p21(ras)
_xantagonists & inhibitors
700 1 _aInoue, Takahiro
700 1 _aTaylor, Rhys Dylan
700 1 _aWatanabe, Takayoshi
700 1 _aKoshikawa, Nobuko
700 1 _aYoda, Hiroyuki
700 1 _aShinohara, Ken-ichi
700 1 _aTakatori, Atsushi
700 1 _aSugimoto, Hirokazu
700 1 _aMaru, Yoshiaki
700 1 _aDenda, Tadamichi
700 1 _aFujiwara, Kyoko
700 1 _aBalmain, Allan
700 1 _aOzaki, Toshinori
700 1 _aBando, Toshikazu
700 1 _aSugiyama, Hiroshi
700 1 _aNagase, Hiroki
773 0 _tNature communications
_gvol. 6
_gp. 6706
856 4 0 _uhttps://doi.org/10.1038/ncomms7706
_zAvailable from publisher's website
999 _c24842977
_d24842977