000 03044 a2200961 4500
005 20250517024700.0
264 0 _c20160331
008 201603s 0 0 eng d
022 _a1932-6203
024 7 _a10.1371/journal.pone.0122271
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aDiogo, Dorothée
245 0 0 _aTYK2 protein-coding variants protect against rheumatoid arthritis and autoimmunity, with no evidence of major pleiotropic effects on non-autoimmune complex traits.
_h[electronic resource]
260 _bPloS one
_c2015
300 _ae0122271 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
650 0 4 _aArthritis, Rheumatoid
_xenzymology
650 0 4 _aAutoimmunity
_xgenetics
650 0 4 _aCell Adhesion Molecules
_xgenetics
650 0 4 _aElectronic Health Records
650 0 4 _aExons
_xgenetics
650 0 4 _aGenetic Loci
_xgenetics
650 0 4 _aGenetic Pleiotropy
650 0 4 _aGenetic Predisposition to Disease
_xgenetics
650 0 4 _aHumans
650 0 4 _aPolymorphism, Single Nucleotide
650 0 4 _aTYK2 Kinase
_xgenetics
700 1 _aBastarache, Lisa
700 1 _aLiao, Katherine P
700 1 _aGraham, Robert R
700 1 _aFulton, Robert S
700 1 _aGreenberg, Jeffrey D
700 1 _aEyre, Steve
700 1 _aBowes, John
700 1 _aCui, Jing
700 1 _aLee, Annette
700 1 _aPappas, Dimitrios A
700 1 _aKremer, Joel M
700 1 _aBarton, Anne
700 1 _aCoenen, Marieke J H
700 1 _aFranke, Barbara
700 1 _aKiemeney, Lambertus A
700 1 _aMariette, Xavier
700 1 _aRichard-Miceli, Corrine
700 1 _aCanhão, Helena
700 1 _aFonseca, João E
700 1 _ade Vries, Niek
700 1 _aTak, Paul P
700 1 _aCrusius, J Bart A
700 1 _aNurmohamed, Michael T
700 1 _aKurreeman, Fina
700 1 _aMikuls, Ted R
700 1 _aOkada, Yukinori
700 1 _aStahl, Eli A
700 1 _aLarson, David E
700 1 _aDeluca, Tracie L
700 1 _aO'Laughlin, Michelle
700 1 _aFronick, Catrina C
700 1 _aFulton, Lucinda L
700 1 _aKosoy, Roman
700 1 _aRansom, Michael
700 1 _aBhangale, Tushar R
700 1 _aOrtmann, Ward
700 1 _aCagan, Andrew
700 1 _aGainer, Vivian
700 1 _aKarlson, Elizabeth W
700 1 _aKohane, Isaac
700 1 _aMurphy, Shawn N
700 1 _aMartin, Javier
700 1 _aZhernakova, Alexandra
700 1 _aKlareskog, Lars
700 1 _aPadyukov, Leonid
700 1 _aWorthington, Jane
700 1 _aMardis, Elaine R
700 1 _aSeldin, Michael F
700 1 _aGregersen, Peter K
700 1 _aBehrens, Timothy
700 1 _aRaychaudhuri, Soumya
700 1 _aDenny, Joshua C
700 1 _aPlenge, Robert M
773 0 _tPloS one
_gvol. 10
_gno. 4
_gp. e0122271
856 4 0 _uhttps://doi.org/10.1371/journal.pone.0122271
_zAvailable from publisher's website
999 _c24781392
_d24781392