000			02266 a2200673 4500
005			20250517012814.0
264		0	_c20150615
008			201506s 0 0 eng d
022			_a1520-4804
024	7		_a10.1021/jm500324g _2doi
040			_aNLM _beng _cNLM
100	1		_aPark, Jin-Hee
245	0	0	_aDiscovery of novel 2,5-dioxoimidazolidine-based P2X(7) receptor antagonists as constrained analogues of KN62. _h[electronic resource]
260			_bJournal of medicinal chemistry _cMar 2015
300			_a2114-34 p. _bdigital
500			_aPublication Type: Journal Article; Research Support, Non-U.S. Gov't
650	0	4	_a1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine _xanalogs & derivatives
650	0	4	_aAnimals
650	0	4	_aArthritis, Experimental _xchemically induced
650	0	4	_aCarrageenan _xtoxicity
650	0	4	_aCattle
650	0	4	_aCollagen Type II _xtoxicity
650	0	4	_aDrug Discovery
650	0	4	_aEdema _xchemically induced
650	0	4	_aEnzyme-Linked Immunosorbent Assay
650	0	4	_aHEK293 Cells
650	0	4	_aHumans
650	0	4	_aHydantoins _xchemistry
650	0	4	_aImmunoblotting
650	0	4	_aInflammation _xchemically induced
650	0	4	_aInterleukin-1beta _xmetabolism
650	0	4	_aLong-Term Potentiation
650	0	4	_aMacrophages _xcytology
650	0	4	_aMale
650	0	4	_aMice, Inbred DBA
650	0	4	_aMolecular Structure
650	0	4	_aMonocytes _xcytology
650	0	4	_aNeuralgia _xdrug therapy
650	0	4	_aPurinergic P2X Receptor Antagonists _xchemistry
650	0	4	_aRats
650	0	4	_aRats, Sprague-Dawley
650	0	4	_aReceptors, Purinergic P2X7 _xchemistry
650	0	4	_aStructure-Activity Relationship
650	0	4	_aSulfonic Acids _xchemistry
650	0	4	_aTissue Distribution
700	1		_aLee, Ga-Eun
700	1		_aLee, So-Deok
700	1		_aHien, Tran Thi
700	1		_aKim, Sujin
700	1		_aYang, Jin Won
700	1		_aCho, Joong-Heui
700	1		_aKo, Hyojin
700	1		_aLim, Sung-Chul
700	1		_aKim, Yoon-Gyoon
700	1		_aKang, Keon-Wook
700	1		_aKim, Yong-Chul
773	0		_tJournal of medicinal chemistry _gvol. 58 _gno. 5 _gp. 2114-34
856	4	0	_uhttps://doi.org/10.1021/jm500324g _zAvailable from publisher's website
999			_c24542213 _d24542213