000			02201 a2200613 4500
005			20250517002947.0
264		0	_c20150217
008			201502s 0 0 eng d
022			_a1520-4995
024	7		_a10.1021/bi501396v _2doi
040			_aNLM _beng _cNLM
100	1		_aSeo, Jeong-Woo
245	0	0	_aComparative characterization of the lactimidomycin and iso-migrastatin biosynthetic machineries revealing unusual features for acyltransferase-less type I polyketide synthases and providing an opportunity to engineer new analogues. _h[electronic resource]
260			_bBiochemistry _cDec 2014
300			_a7854-65 p. _bdigital
500			_aPublication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
650	0	4	_aAntibiotics, Antineoplastic _xbiosynthesis
650	0	4	_aBacterial Proteins _xantagonists & inhibitors
650	0	4	_aBase Sequence
650	0	4	_aBioreactors
650	0	4	_aCell Line, Tumor
650	0	4	_aCell Survival _xdrug effects
650	0	4	_aDrug Design
650	0	4	_aGene Silencing
650	0	4	_aHumans
650	0	4	_aMacrolides _xchemistry
650	0	4	_aModels, Biological
650	0	4	_aMolecular Sequence Data
650	0	4	_aMolecular Structure
650	0	4	_aMultigene Family
650	0	4	_aMutant Proteins _xchemistry
650	0	4	_aNeoplasms _xdrug therapy
650	0	4	_aPiperidones _xchemistry
650	0	4	_aPolyketide Synthases _xantagonists & inhibitors
650	0	4	_aPolyketides _xchemistry
650	0	4	_aProtein Engineering
650	0	4	_aRecombinant Proteins _xchemistry
650	0	4	_aStereoisomerism
650	0	4	_aStreptomyces _xenzymology
650	0	4	_aStructure-Activity Relationship
700	1		_aMa, Ming
700	1		_aKwong, Thomas
700	1		_aJu, Jianhua
700	1		_aLim, Si-Kyu
700	1		_aJiang, Hui
700	1		_aLohman, Jeremy R
700	1		_aYang, Chunying
700	1		_aCleveland, John
700	1		_aZazopoulos, Emmanuel
700	1		_aFarnet, Chris M
700	1		_aShen, Ben
773	0		_tBiochemistry _gvol. 53 _gno. 49 _gp. 7854-65
856	4	0	_uhttps://doi.org/10.1021/bi501396v _zAvailable from publisher's website
999			_c24362399 _d24362399