| 000 | 03152 a2200961 4500 | ||
|---|---|---|---|
| 005 | 20250517002815.0 | ||
| 264 | 0 | _c20150427 | |
| 008 | 201504s 0 0 eng d | ||
| 022 | _a1520-4804 | ||
| 024 | 7 |
_a10.1021/jm5013352 _2doi |
|
| 040 |
_aNLM _beng _cNLM |
||
| 100 | 1 | _aPasquier, Benoit | |
| 245 | 0 | 0 |
_aDiscovery of (2S)-8-[(3R)-3-methylmorpholin-4-yl]-1-(3-methyl-2-oxobutyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido[1,2-a]pyrimidin-6-one: a novel potent and selective inhibitor of Vps34 for the treatment of solid tumors. _h[electronic resource] |
| 260 |
_bJournal of medicinal chemistry _cJan 2015 |
||
| 300 |
_a376-400 p. _bdigital |
||
| 500 | _aPublication Type: Journal Article | ||
| 650 | 0 | 4 | _aAmino Acid Sequence |
| 650 | 0 | 4 | _aAnimals |
| 650 | 0 | 4 |
_aAntineoplastic Agents _xchemistry |
| 650 | 0 | 4 | _aArea Under Curve |
| 650 | 0 | 4 |
_aBridged Bicyclo Compounds, Heterocyclic _xchemistry |
| 650 | 0 | 4 | _aCaco-2 Cells |
| 650 | 0 | 4 | _aCell Line, Tumor |
| 650 | 0 | 4 |
_aClass III Phosphatidylinositol 3-Kinases _xantagonists & inhibitors |
| 650 | 0 | 4 | _aCrystallography, X-Ray |
| 650 | 0 | 4 | _aDrug Discovery |
| 650 | 0 | 4 |
_aEnzyme Inhibitors _xchemistry |
| 650 | 0 | 4 | _aHeLa Cells |
| 650 | 0 | 4 | _aHumans |
| 650 | 0 | 4 | _aMale |
| 650 | 0 | 4 | _aMice, SCID |
| 650 | 0 | 4 | _aModels, Chemical |
| 650 | 0 | 4 | _aModels, Molecular |
| 650 | 0 | 4 | _aMolecular Sequence Data |
| 650 | 0 | 4 | _aMolecular Structure |
| 650 | 0 | 4 |
_aNeoplasms _xdrug therapy |
| 650 | 0 | 4 | _aProtein Binding |
| 650 | 0 | 4 | _aProtein Structure, Tertiary |
| 650 | 0 | 4 |
_aPyrimidinones _xchemistry |
| 650 | 0 | 4 | _aRats, Sprague-Dawley |
| 650 | 0 | 4 | _aSequence Homology, Amino Acid |
| 650 | 0 | 4 | _aThermodynamics |
| 650 | 0 | 4 | _aXenograft Model Antitumor Assays |
| 700 | 1 | _aEl-Ahmad, Youssef | |
| 700 | 1 | _aFiloche-Rommé, Bruno | |
| 700 | 1 | _aDureuil, Christine | |
| 700 | 1 | _aFassy, Florence | |
| 700 | 1 | _aAbecassis, Pierre-Yves | |
| 700 | 1 | _aMathieu, Magali | |
| 700 | 1 | _aBertrand, Thomas | |
| 700 | 1 | _aBenard, Tsiala | |
| 700 | 1 | _aBarrière, Cédric | |
| 700 | 1 | _aEl Batti, Samira | |
| 700 | 1 | _aLetallec, Jean-Philippe | |
| 700 | 1 | _aSonnefraud, Véronique | |
| 700 | 1 | _aBrollo, Maurice | |
| 700 | 1 | _aDelbarre, Laurence | |
| 700 | 1 | _aLoyau, Véronique | |
| 700 | 1 | _aPilorge, Fabienne | |
| 700 | 1 | _aBertin, Luc | |
| 700 | 1 | _aRichepin, Patrick | |
| 700 | 1 | _aArigon, Jérôme | |
| 700 | 1 | _aLabrosse, Jean-Robert | |
| 700 | 1 | _aClément, Jacques | |
| 700 | 1 | _aDurand, Florence | |
| 700 | 1 | _aCombet, Romain | |
| 700 | 1 | _aPerraut, Pierre | |
| 700 | 1 | _aLeroy, Vincent | |
| 700 | 1 | _aGay, Frédéric | |
| 700 | 1 | _aLefrançois, Dominique | |
| 700 | 1 | _aBretin, François | |
| 700 | 1 | _aMarquette, Jean-Pierre | |
| 700 | 1 | _aMichot, Nadine | |
| 700 | 1 | _aCaron, Anne | |
| 700 | 1 | _aCastell, Christelle | |
| 700 | 1 | _aSchio, Laurent | |
| 700 | 1 | _aMcCort, Gary | |
| 700 | 1 | _aGoulaouic, Hélène | |
| 700 | 1 | _aGarcia-Echeverria, Carlos | |
| 700 | 1 | _aRonan, Baptiste | |
| 773 | 0 |
_tJournal of medicinal chemistry _gvol. 58 _gno. 1 _gp. 376-400 |
|
| 856 | 4 | 0 |
_uhttps://doi.org/10.1021/jm5013352 _zAvailable from publisher's website |
| 999 |
_c24358907 _d24358907 |
||