000			01960 a2200553 4500
005			20250517002318.0
264		0	_c20151124
008			201511s 0 0 eng d
022			_a1521-009X
024	7		_a10.1124/dmd.114.061218 _2doi
040			_aNLM _beng _cNLM
100	1		_aSharma, Raman
245	0	0	_aComparison of the circulating metabolite profile of PF-04991532, a hepatoselective glucokinase activator, across preclinical species and humans: potential implications in metabolites in safety testing assessment. _h[electronic resource]
260			_bDrug metabolism and disposition: the biological fate of chemicals _cFeb 2015
300			_a190-8 p. _bdigital
500			_aPublication Type: Clinical Trial, Phase I; Comparative Study; Journal Article
650	0	4	_aAged
650	0	4	_aAnimals
650	0	4	_aAnimals, Inbred Strains
650	0	4	_aBiotransformation
650	0	4	_aCarbon Radioisotopes
650	0	4	_aDogs
650	0	4	_aDrug Evaluation, Preclinical
650	0	4	_aEnzyme Activators _xanalysis
650	0	4	_aFeces _xchemistry
650	0	4	_aFemale
650	0	4	_aGlucokinase _xchemistry
650	0	4	_aHalf-Life
650	0	4	_aHumans
650	0	4	_aHypoglycemic Agents _xanalysis
650	0	4	_aImidazoles _xanalysis
650	0	4	_aLiver _xdrug effects
650	0	4	_aMale
650	0	4	_aMiddle Aged
650	0	4	_aMolecular Structure
650	0	4	_aNicotinic Acids _xanalysis
650	0	4	_aOrgan Specificity
650	0	4	_aRats, Sprague-Dawley
700	1		_aLitchfield, John
700	1		_aBergman, Arthur
700	1		_aAtkinson, Karen
700	1		_aKazierad, David
700	1		_aGustavson, Stephanie M
700	1		_aDi, Li
700	1		_aPfefferkorn, Jeffrey A
700	1		_aKalgutkar, Amit S
773	0		_tDrug metabolism and disposition: the biological fate of chemicals _gvol. 43 _gno. 2 _gp. 190-8
856	4	0	_uhttps://doi.org/10.1124/dmd.114.061218 _zAvailable from publisher's website
999			_c24343022 _d24343022