000 01518 a2200409 4500
005 20250517000950.0
264 0 _c20150914
008 201509s 0 0 eng d
022 _a1545-326X
024 7 _a10.1146/annurev-med-050913-022545
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aLord, Christopher J
245 0 0 _aSynthetic lethality and cancer therapy: lessons learned from the development of PARP inhibitors.
_h[electronic resource]
260 _bAnnual review of medicine
_c2015
300 _a455-70 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, Non-U.S. Gov't; Review
650 0 4 _aBenzamides
_xtherapeutic use
650 0 4 _aBreast Neoplasms
_xdrug therapy
650 0 4 _aDrug Resistance, Neoplasm
650 0 4 _aEnzyme Inhibitors
_xtherapeutic use
650 0 4 _aFemale
650 0 4 _aGenes, BRCA1
650 0 4 _aGenes, BRCA2
650 0 4 _aHumans
650 0 4 _aMutation
650 0 4 _aNeoplasms
_xdrug therapy
650 0 4 _aNeoplasms, Cystic, Mucinous, and Serous
_xdrug therapy
650 0 4 _aOvarian Neoplasms
_xdrug therapy
650 0 4 _aPhthalazines
_xtherapeutic use
650 0 4 _aPiperazines
_xtherapeutic use
650 0 4 _aPoly (ADP-Ribose) Polymerase-1
650 0 4 _aPoly(ADP-ribose) Polymerase Inhibitors
700 1 _aTutt, Andrew N J
700 1 _aAshworth, Alan
773 0 _tAnnual review of medicine
_gvol. 66
_gp. 455-70
856 4 0 _uhttps://doi.org/10.1146/annurev-med-050913-022545
_zAvailable from publisher's website
999 _c24301986
_d24301986