000 02047 a2200529 4500
005 20250517000443.0
264 0 _c20151116
008 201511s 0 0 eng d
022 _a1755-148X
024 7 _a10.1111/pcmr.12325
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aLiu, Yubo
245 0 0 _aA novel BH3 mimetic efficiently induces apoptosis in melanoma cells through direct binding to anti-apoptotic Bcl-2 family proteins, including phosphorylated Mcl-1.
_h[electronic resource]
260 _bPigment cell & melanoma research
_cMar 2015
300 _a161-70 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, Non-U.S. Gov't
650 0 4 _aAnimals
650 0 4 _aAntineoplastic Agents
_xchemistry
650 0 4 _aApoptosis
_xdrug effects
650 0 4 _aApoptosis Regulatory Proteins
_xmetabolism
650 0 4 _aBcl-2-Like Protein 11
650 0 4 _aCaspases
_xmetabolism
650 0 4 _aCell Line, Tumor
650 0 4 _aExtracellular Signal-Regulated MAP Kinases
_xmetabolism
650 0 4 _aGossypol
_xpharmacology
650 0 4 _aHumans
650 0 4 _aJNK Mitogen-Activated Protein Kinases
_xmetabolism
650 0 4 _aMelanoma
_xpathology
650 0 4 _aMembrane Proteins
_xmetabolism
650 0 4 _aMice
650 0 4 _aMitochondria
_xdrug effects
650 0 4 _aMyeloid Cell Leukemia Sequence 1 Protein
_xmetabolism
650 0 4 _aPhosphorylation
_xdrug effects
650 0 4 _aProteolysis
_xdrug effects
650 0 4 _aProto-Oncogene Proteins
_xmetabolism
650 0 4 _aProto-Oncogene Proteins c-bcl-2
_xmetabolism
650 0 4 _aSignal Transduction
_xdrug effects
650 0 4 _aSubstrate Specificity
_xdrug effects
650 0 4 _abcl-2 Homologous Antagonist-Killer Protein
_xmetabolism
700 1 _aXie, Mingzhou
700 1 _aSong, Ting
700 1 _aSheng, Hongkun
700 1 _aYu, Xiaoyan
700 1 _aZhang, Zhichao
773 0 _tPigment cell & melanoma research
_gvol. 28
_gno. 2
_gp. 161-70
856 4 0 _uhttps://doi.org/10.1111/pcmr.12325
_zAvailable from publisher's website
999 _c24286939
_d24286939