000 02374 a2200613 4500
005 20250516233525.0
264 0 _c20150709
008 201507s 0 0 eng d
022 _a1557-3265
024 7 _a10.1158/1078-0432.CCR-14-1511
_2doi
040 _aNLM
_beng
_cNLM
100 1 _aKatayama, Ryohei
245 0 0 _aTwo novel ALK mutations mediate acquired resistance to the next-generation ALK inhibitor alectinib.
_h[electronic resource]
260 _bClinical cancer research : an official journal of the American Association for Cancer Research
_cNov 2014
300 _a5686-96 p.
_bdigital
500 _aPublication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
650 0 4 _aAnaplastic Lymphoma Kinase
650 0 4 _aBenzoquinones
_xpharmacology
650 0 4 _aCarbazoles
_xpharmacology
650 0 4 _aCarcinoma, Non-Small-Cell Lung
_xdiagnostic imaging
650 0 4 _aCell Line, Tumor
650 0 4 _aCrizotinib
650 0 4 _aDNA Mutational Analysis
650 0 4 _aDose-Response Relationship, Drug
650 0 4 _aDrug Resistance, Neoplasm
_xgenetics
650 0 4 _aHSP90 Heat-Shock Proteins
_xantagonists & inhibitors
650 0 4 _aHumans
650 0 4 _aInhibitory Concentration 50
650 0 4 _aLactams, Macrocyclic
_xpharmacology
650 0 4 _aLung Neoplasms
_xdiagnostic imaging
650 0 4 _aModels, Molecular
650 0 4 _aMutation
650 0 4 _aPiperidines
_xpharmacology
650 0 4 _aProtein Conformation
650 0 4 _aProtein Kinase Inhibitors
_xpharmacology
650 0 4 _aPyrazoles
_xpharmacology
650 0 4 _aPyridines
_xpharmacology
650 0 4 _aReceptor Protein-Tyrosine Kinases
_xantagonists & inhibitors
650 0 4 _aTomography, X-Ray Computed
700 1 _aFriboulet, Luc
700 1 _aKoike, Sumie
700 1 _aLockerman, Elizabeth L
700 1 _aKhan, Tahsin M
700 1 _aGainor, Justin F
700 1 _aIafrate, A John
700 1 _aTakeuchi, Kengo
700 1 _aTaiji, Makoto
700 1 _aOkuno, Yasushi
700 1 _aFujita, Naoya
700 1 _aEngelman, Jeffrey A
700 1 _aShaw, Alice T
773 0 _tClinical cancer research : an official journal of the American Association for Cancer Research
_gvol. 20
_gno. 22
_gp. 5686-96
856 4 0 _uhttps://doi.org/10.1158/1078-0432.CCR-14-1511
_zAvailable from publisher's website
999 _c24197506
_d24197506