000			02263 a2200613 4500
005			20250516225435.0
264		0	_c20141125
008			201411s 0 0 eng d
022			_a1521-0103
024	7		_a10.1124/jpet.114.216861 _2doi
040			_aNLM _beng _cNLM
100	1		_aHegde, Sharath S
245	0	0	_aPharmacologic characterization of GSK-961081 (TD-5959), a first-in-class inhaled bifunctional bronchodilator possessing muscarinic receptor antagonist and β2-adrenoceptor agonist properties. _h[electronic resource]
260			_bThe Journal of pharmacology and experimental therapeutics _cOct 2014
300			_a190-9 p. _bdigital
500			_aPublication Type: Journal Article; Research Support, Non-U.S. Gov't
650	0	4	_aAdrenergic beta-2 Receptor Antagonists _xadverse effects
650	0	4	_aAlbuterol _xanalogs & derivatives
650	0	4	_aAnimals
650	0	4	_aBronchodilator Agents _xadverse effects
650	0	4	_aCHO Cells
650	0	4	_aCarbamates _xadverse effects
650	0	4	_aCricetinae
650	0	4	_aCricetulus
650	0	4	_aCyclic AMP _xmetabolism
650	0	4	_aDrug Evaluation, Preclinical
650	0	4	_aGuinea Pigs
650	0	4	_aHEK293 Cells
650	0	4	_aHumans
650	0	4	_aLung _xdrug effects
650	0	4	_aMuscarinic Antagonists _xadverse effects
650	0	4	_aMuscle Relaxation
650	0	4	_aMuscle, Smooth _xdrug effects
650	0	4	_aProtein Binding
650	0	4	_aQuinolones _xadverse effects
650	0	4	_aReceptors, Adrenergic, beta _xmetabolism
650	0	4	_aReceptors, Muscarinic _xmetabolism
650	0	4	_aSalmeterol Xinafoate
650	0	4	_aScopolamine Derivatives _xpharmacokinetics
650	0	4	_aTiotropium Bromide
650	0	4	_aTissue Distribution
650	0	4	_aTrachea _xdrug effects
700	1		_aHughes, Adam D
700	1		_aChen, Yan
700	1		_aSteinfeld, Tod
700	1		_aJasper, Jeffrey R
700	1		_aLee, Tae-Weon
700	1		_aMcNamara, Alexander
700	1		_aMartin, William J
700	1		_aPulido-Rios, M Teresa
700	1		_aMammen, Mathai
773	0		_tThe Journal of pharmacology and experimental therapeutics _gvol. 351 _gno. 1 _gp. 190-9
856	4	0	_uhttps://doi.org/10.1124/jpet.114.216861 _zAvailable from publisher's website
999			_c24077458 _d24077458