| 000 | 02393 a2200721 4500 | ||
|---|---|---|---|
| 005 | 20250516225432.0 | ||
| 264 | 0 | _c20141203 | |
| 008 | 201412s 0 0 eng d | ||
| 022 | _a1520-4804 | ||
| 024 | 7 |
_a10.1021/jm500916t _2doi |
|
| 040 |
_aNLM _beng _cNLM |
||
| 100 | 1 | _aVoight, Eric A | |
| 245 | 0 | 0 |
_aDiscovery of (R)-1-(7-chloro-2,2-bis(fluoromethyl)chroman-4-yl)-3-(3-methylisoquinolin-5-yl)urea (A-1165442): a temperature-neutral transient receptor potential vanilloid-1 (TRPV1) antagonist with analgesic efficacy. _h[electronic resource] |
| 260 |
_bJournal of medicinal chemistry _cSep 2014 |
||
| 300 |
_a7412-24 p. _bdigital |
||
| 500 | _aPublication Type: Journal Article; Research Support, Non-U.S. Gov't | ||
| 650 | 0 | 4 |
_aAnalgesics _xchemistry |
| 650 | 0 | 4 | _aAnimals |
| 650 | 0 | 4 | _aArea Under Curve |
| 650 | 0 | 4 |
_aBody Temperature _xdrug effects |
| 650 | 0 | 4 | _aDogs |
| 650 | 0 | 4 | _aDose-Response Relationship, Drug |
| 650 | 0 | 4 | _aDrug Discovery |
| 650 | 0 | 4 | _aHEK293 Cells |
| 650 | 0 | 4 | _aHumans |
| 650 | 0 | 4 |
_aIsoquinolines _xchemistry |
| 650 | 0 | 4 | _aMetabolic Clearance Rate |
| 650 | 0 | 4 | _aModels, Chemical |
| 650 | 0 | 4 | _aMolecular Structure |
| 650 | 0 | 4 | _aRats |
| 650 | 0 | 4 | _aStructure-Activity Relationship |
| 650 | 0 | 4 |
_aTRPV Cation Channels _xantagonists & inhibitors |
| 650 | 0 | 4 |
_aUrea _xanalogs & derivatives |
| 700 | 1 | _aGomtsyan, Arthur R | |
| 700 | 1 | _aDaanen, Jerome F | |
| 700 | 1 | _aPerner, Richard J | |
| 700 | 1 | _aSchmidt, Robert G | |
| 700 | 1 | _aBayburt, Erol K | |
| 700 | 1 | _aDiDomenico, Stanley | |
| 700 | 1 | _aMcDonald, Heath A | |
| 700 | 1 | _aPuttfarcken, Pamela S | |
| 700 | 1 | _aChen, Jun | |
| 700 | 1 | _aNeelands, Torben R | |
| 700 | 1 | _aBianchi, Bruce R | |
| 700 | 1 | _aHan, Ping | |
| 700 | 1 | _aReilly, Regina M | |
| 700 | 1 | _aFranklin, Pamela H | |
| 700 | 1 | _aSegreti, Jason A | |
| 700 | 1 | _aNelson, Richard A | |
| 700 | 1 | _aSu, Zhi | |
| 700 | 1 | _aKing, Andrew J | |
| 700 | 1 | _aPolakowski, James S | |
| 700 | 1 | _aBaker, Scott J | |
| 700 | 1 | _aGauvin, Donna M | |
| 700 | 1 | _aLewis, LaGeisha R | |
| 700 | 1 | _aMikusa, Joseph P | |
| 700 | 1 | _aJoshi, Shailen K | |
| 700 | 1 | _aFaltynek, Connie R | |
| 700 | 1 | _aKym, Philip R | |
| 700 | 1 | _aKort, Michael E | |
| 773 | 0 |
_tJournal of medicinal chemistry _gvol. 57 _gno. 17 _gp. 7412-24 |
|
| 856 | 4 | 0 |
_uhttps://doi.org/10.1021/jm500916t _zAvailable from publisher's website |
| 999 |
_c24077279 _d24077279 |
||