| 000 | 01774 a2200457 4500 | ||
|---|---|---|---|
| 005 | 20250516224001.0 | ||
| 264 | 0 | _c20150128 | |
| 008 | 201501s 0 0 eng d | ||
| 022 | _a1083-351X | ||
| 024 | 7 |
_a10.1074/jbc.M114.583021 _2doi |
|
| 040 |
_aNLM _beng _cNLM |
||
| 100 | 1 | _aLoo, Tip W | |
| 245 | 0 | 0 |
_aCysteines introduced into extracellular loops 1 and 4 of human P-glycoprotein that are close only in the open conformation spontaneously form a disulfide bond that inhibits drug efflux and ATPase activity. _h[electronic resource] |
| 260 |
_bThe Journal of biological chemistry _cSep 2014 |
||
| 300 |
_a24749-58 p. _bdigital |
||
| 500 | _aPublication Type: Journal Article; Research Support, Non-U.S. Gov't | ||
| 650 | 0 | 4 |
_aATP Binding Cassette Transporter, Subfamily B _xchemistry |
| 650 | 0 | 4 |
_aAdenosine Triphosphatases _xmetabolism |
| 650 | 0 | 4 |
_aAdenosine Triphosphate _xmetabolism |
| 650 | 0 | 4 | _aAnimals |
| 650 | 0 | 4 |
_aBinding Sites _xgenetics |
| 650 | 0 | 4 | _aCell Line |
| 650 | 0 | 4 |
_aCysteine _xchemistry |
| 650 | 0 | 4 |
_aDisulfides _xchemistry |
| 650 | 0 | 4 |
_aDithiothreitol _xpharmacology |
| 650 | 0 | 4 |
_aDrug Resistance, Multiple _xdrug effects |
| 650 | 0 | 4 |
_aGlycoside Hydrolases _xmetabolism |
| 650 | 0 | 4 | _aHEK293 Cells |
| 650 | 0 | 4 | _aHumans |
| 650 | 0 | 4 | _aHydrolysis |
| 650 | 0 | 4 | _aImmunoblotting |
| 650 | 0 | 4 | _aModels, Molecular |
| 650 | 0 | 4 | _aMutation |
| 650 | 0 | 4 |
_aPharmaceutical Preparations _xmetabolism |
| 650 | 0 | 4 | _aProtein Conformation |
| 650 | 0 | 4 | _aProtein Structure, Secondary |
| 650 | 0 | 4 | _aProtein Structure, Tertiary |
| 700 | 1 | _aClarke, David M | |
| 773 | 0 |
_tThe Journal of biological chemistry _gvol. 289 _gno. 36 _gp. 24749-58 |
|
| 856 | 4 | 0 |
_uhttps://doi.org/10.1074/jbc.M114.583021 _zAvailable from publisher's website |
| 999 |
_c24034554 _d24034554 |
||