| 000 | 01819 a2200481 4500 | ||
|---|---|---|---|
| 005 | 20250516221851.0 | ||
| 264 | 0 | _c20141021 | |
| 008 | 201410s 0 0 eng d | ||
| 022 | _a1520-4804 | ||
| 024 | 7 |
_a10.1021/jm500378a _2doi |
|
| 040 |
_aNLM _beng _cNLM |
||
| 100 | 1 | _aFelding, Jakob | |
| 245 | 0 | 0 |
_aDiscovery and early clinical development of 2-{6-[2-(3,5-dichloro-4-pyridyl)acetyl]-2,3-dimethoxyphenoxy}-N-propylacetamide (LEO 29102), a soft-drug inhibitor of phosphodiesterase 4 for topical treatment of atopic dermatitis. _h[electronic resource] |
| 260 |
_bJournal of medicinal chemistry _cJul 2014 |
||
| 300 |
_a5893-903 p. _bdigital |
||
| 500 | _aPublication Type: Journal Article; Review | ||
| 650 | 0 | 4 |
_aAcetamides _xchemical synthesis |
| 650 | 0 | 4 | _aCrystallography, X-Ray |
| 650 | 0 | 4 |
_aCyclic Nucleotide Phosphodiesterases, Type 4 _xmetabolism |
| 650 | 0 | 4 |
_aDermatitis, Atopic _xdrug therapy |
| 650 | 0 | 4 | _aDose-Response Relationship, Drug |
| 650 | 0 | 4 | _aDrug Discovery |
| 650 | 0 | 4 | _aHumans |
| 650 | 0 | 4 | _aModels, Molecular |
| 650 | 0 | 4 | _aMolecular Structure |
| 650 | 0 | 4 |
_aPhosphodiesterase 4 Inhibitors _xchemical synthesis |
| 650 | 0 | 4 |
_aPyridines _xchemical synthesis |
| 650 | 0 | 4 | _aStructure-Activity Relationship |
| 700 | 1 | _aSørensen, Morten D | |
| 700 | 1 | _aPoulsen, Tina D | |
| 700 | 1 | _aLarsen, Jens | |
| 700 | 1 | _aAndersson, Christina | |
| 700 | 1 | _aRefer, Pia | |
| 700 | 1 | _aEngell, Karen | |
| 700 | 1 | _aLadefoged, Lotte G | |
| 700 | 1 | _aThormann, Thorsten | |
| 700 | 1 | _aVinggaard, Anne Marie | |
| 700 | 1 | _aHegardt, Pontus | |
| 700 | 1 | _aSøhoel, Anders | |
| 700 | 1 | _aNielsen, Simon Feldbæk | |
| 773 | 0 |
_tJournal of medicinal chemistry _gvol. 57 _gno. 14 _gp. 5893-903 |
|
| 856 | 4 | 0 |
_uhttps://doi.org/10.1021/jm500378a _zAvailable from publisher's website |
| 999 |
_c23971352 _d23971352 |
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